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Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients

机译：头颈患者循环肿瘤细胞的纳米医疗检测与下游分析

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The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian and prostate cancers. Thus, the detection of circulating tumor cells seems to be also applicable for minimal-invasive monitoring of therapy progress in head and neck cancer patients. A major problem of the use in clinical routine is that circulating tumor cells could not be detected by modern imaging techniques. To overcome these limitations highly sensitive detection methods and techniques for their molecular characterization are urgently needed allowing mechanistic understanding and targeting of circulating tumor cells. Especially the medical application of nanotechnology (nanomedical methods) has made valuable contributions to the field. Here, we want to provide a comprehensive overview on (nanomedical) detection methods for circulating tumor cells and discuss their merits, pitfalls and future perspectives especially for head and neck solid squamous cell carcinoma (HNSCC) patients.
机译：建立癌症患者液体活组织检查的新型生物标志物已经进入预后和诊断研究努力。由于它们的预后相关性传播肿瘤细胞或循环肿瘤细胞是密集研究的主题，并且被讨论为治疗失败的早期诊断指标和微转移酶的形成。对于包括乳腺癌，结肠，肺，黑素瘤，卵巢和前列腺癌，卵巢和前列腺癌的各个实体，可以证明这种早期全身肿瘤成分具有差的癌症患者预后差的潜在协会。因此，循环肿瘤细胞的检测似乎也适用于头部和颈部癌症患者治疗进展的最小侵袭监测。在临床常规中使用的主要问题是通过现代成像技术无法检测到循环肿瘤细胞。为了克服这些限制，迫切需要高灵敏度检测方法和技术的分子表征，允许机械理解和靶向循环肿瘤细胞。特别是纳米技术（纳米医疗方法）的医学应用对该领域的贡献产生了宝贵的贡献。在这里，我们希望提供全面的概述（纳米医科）检测方法，用于循环肿瘤细胞，讨论其优点，陷阱和未来的观点，特别是对于头部和颈部固体鳞状细胞癌（HNSCC）患者。

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