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首页> 外文期刊>Cytokine >VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer.
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VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer.

机译：口腔癌患者中性粒细胞产生的VEGF，IL-18和NO及其血清水平

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It is known that the relationship between pro-angiogenic and anti-angiogenic factors is responsible for the presence and intensity of neoangiogenesis. The angiogenic factors are produced by tumour cells and/or by tumour-infiltrating inflammatory cells such as macrophages or polymorphonuclear leukocytes (PMN). In the present study we compared VEGF secretion with IL-18 and NO release by PMN derived from oral cavity cancer patients. Knowledge of the relationship between mediators above could help in better understanding the role of PMN in angiogenesis in this patient group. The results from culture supernatants of PMN were confronted with the serum levels of parameters examined. We found an interesting relationship between VEGF and IL-18 concentrations in the culture supernatants of PMN derived from patients with oral cavity cancer. High production of VEGF was associated with low production of IL-18 by PMN derived from patients before treatment. During examinations after treatment we found lower concentrations of VEGF and higher concentrations of IL-18 than those in the study before treatment. In contrast to VEGF and IL-18, the NO production by PMN of cancer patients, before and after treatment, was unchanged. We also demonstrated markedly elevated serum levels of VEGF as well as IL-18 according to the progression of the disease. Results obtained indicate that relations between VEGF and IL-18 released by PMN may promote neoangiogenesis and may be important for benign tumour cells to acquire metastatic phenotype in the early stage of oral cavity cancer. Furthermore, our results suggest that the concentrations of VEGF and IL-18 in the serum are sensitive tumour markers in this patient group before and after treatment.
机译：已知促血管生成因子和抗血管生成因子之间的关系是新血管生成的存在和强度的原因。血管生成因子由肿瘤细胞和/或肿瘤浸润的炎性细胞例如巨噬细胞或多形核白细胞（PMN）产生。在本研究中，我们比较了来自口腔癌患者的PMN分泌的VEGF分泌与IL-18和NO的释放。了解以上介体之间的关系可能有助于更好地了解该患者组中PMN在血管生成中的作用。 PMN培养上清液的结果与所检测参数的血清水平相对。我们发现来自口腔癌患者的PMN培养上清液中VEGF和IL-18浓度之间存在有趣的关系。治疗前源自患者的PMN产生的高VEGF与低表达IL-18有关。在治疗后的检查中，我们发现与治疗前相比，VEGF的浓度较低，IL-18的浓度较高。与VEGF和IL-18相反，在治疗前后，癌症患者PMN产生的NO保持不变。根据疾病的进展，我们还证明了血清VEGF和IL-18的水平明显升高。获得的结果表明，PMN释放的VEGF与IL-18之间的关系可能促进新生血管生成，对于良性肿瘤细胞在口腔癌的早期阶段获得转移表型可能很重要。此外，我们的结果表明，该患者组治疗前后血清中VEGF和IL-18的浓度是敏感的肿瘤标志物。

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