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首页> 外文期刊>Cytokine >Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
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Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.

机译：甲磺酸加贝酯对急性坏死性胰腺炎大鼠血清炎性细胞因子的影响。

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摘要

Gabexate mesilate is a synthetic protease inhibitor. The effectiveness of gabexate mesilate in patients with acute pancreatitis is controversial. Proinflammatory cytokines are associated with systemic inflammatory response syndrome (SIRS) in acute pancreatitis. A compensatory anti-inflammatory response occurs in parallel with SIRS. We investigated the effects of gabexate mesilate on acute necrotizing pancreatitis in rats, emphasizing the changes in serum levels of proinflammatory and anti-inflammatory cytokines. Acute necrotizing pancreatitis was induced by retrograde infusion of sodium taurodeoxycholate into the pancreatobiliary duct in rats. The rats were divided into three groups. Group I was given gabexate mesilate 2 mg/kg/h i.v. continuously 1 h before the induction of acute pancreatitis. Group II was given gabexate mesilate the same dose immediately after the induction of acute pancreatitis. Group III was given normal saline as the controls. Serum levels of amylase, lipase, tumor necrosis factor alpha, interleukin-6, and interleukin-10, pancreatic histopathology and hemodynamics were examined at 5h after the induction of acute pancreatitis. Gabexate mesilate significantly reduced serum levels of amylase, lipase, tumor necrosis factor alpha and interleukin-6 at 5 h. Serum levels of interleukin-10 significantly increased in Group I, as compared with Groups II and III. The severity of pancreatic histopathology, the reduction of mean arterial pressure, the volume of ascites and pancreatic wet weight/body weight ratios were also significantly improved by the administration of gabexate mesilate. The beneficial effects of gabexate mesilate on acute pancreatitis may be, in part, due to the modulation of inflammatory cytokine responses.
机译：甲磺酸加倍酯是一种合成蛋白酶抑制剂。甲磺酸加贝酸酯在急性胰腺炎患者中的有效性存在争议。在急性胰腺炎中，促炎细胞因子与全身性炎症反应综合征（SIRS）相关。代偿性抗炎反应与SIRS同时发生。我们调查了甲磺酸加贝酸酯对大鼠急性坏死性胰腺炎的影响，强调了血清促炎和抗炎细胞因子水平的变化。通过向大鼠胰胆管逆行输注牛磺脱氧胆酸钠来诱发急性坏死性胰腺炎。将大鼠分为三组。第一组静脉注射甲磺酸依加比酯2 mg / kg / h。在诱发急性胰腺炎之前连续1 h。急性胰腺炎诱发后，立即向II组给予相同剂量的甲磺酸加贝酯。第三组给予生理盐水作为对照。在诱发急性胰腺炎后5小时，检查血清淀粉酶，脂肪酶，肿瘤坏死因子α，白细胞介素6和白细胞介素10的水平，胰腺组织病理学和血液动力学。甲磺酸加贝酯在5 h时可显着降低血清淀粉酶，脂肪酶，肿瘤坏死因子α和白介素6的水平。与第二组和第三组相比，第一组的血清白细胞介素10水平显着增加。甲磺酸加贝酯可显着改善胰腺组织病理学的严重程度，平均动脉压的降低，腹水量和胰腺湿重/体重比。甲磺酸加贝酯对急性胰腺炎的有益作用可能部分归因于炎症性细胞因子反应的调节。

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