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首页> 外文期刊>Biomaterials Science >PA/US dual-modality imaging to guide VEGFR-2 targeted photothermal therapy using ZnPc-/PFH-loaded polymeric nanoparticles
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PA/US dual-modality imaging to guide VEGFR-2 targeted photothermal therapy using ZnPc-/PFH-loaded polymeric nanoparticles

机译：PA / US双模成像以指导VEGFR-2使用ZnPC-/ PFH加载聚合物纳米颗粒的靶向光热疗法

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摘要

Angiogenesis is a common pathological characteristic of many solid tumors and vulnerable atherosclerotic plaques. Photothermal therapy (PTT) is a promising method to reduce neovascularization. To increase the targeting ability and efficiency of PTT, a novel polymeric nanosystem that encapsulates phthalocyanine zinc (ZnPc) and perfluorohexane (PFH) was developed to target the new blood vessels of breast tumors. After being conjugated to the anti-VEGFR-2 antibody, the polymeric nanoparticles (NPs) targeted vascular endothelial cells efficiently. The photosensitizer (PS) in the NPs could convert laser energy into heat, generating local high temperatures to kill the surrounding cells under laser irradiation. In addition, the liquid-gas phase transition of PFH was induced, and an enhanced ultrasound (US) and photoacoustic (PA) image could be obtained. US/PA imaging enables visualization of the location of NPs, and laser irradiation position can be guided to the optimal location, resulting in fewer side effects than those from traditional treatments with a high targeting ability and an efficient synergistic effect from the PTT.
机译：血管生成是许多实体瘤和脆弱的动脉粥样硬化斑块的常见病理特征。光热疗（PTT）是减少新血管形成的有希望的方法。为了提高PTT的靶向能力和效率，开发了一种新型聚合物纳米组合，其包封酞菁锌（ZnPC）和全氟己烷（PFH）以靶向乳腺肿瘤的新血管。在与抗VEGFR-2抗体缀合后，聚合物纳米颗粒（NPS）有效地靶向血管内皮细胞。 NPS中的光敏剂（PS）可以将激光能量转化为热量，产生局部高温，以在激光照射下杀死周围的细胞。此外，诱导PFH的液体 - 气相转变，并且可以获得增强的超声（US）和光声（PA）图像。 US / PA成像使得能够可视化NPS的位置，激光照射位置可以被引导至最佳位置，从而较少的副作用比来自具有高靶向能力的传统治疗和来自PTT的有效协同效应的副作用。

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  • 来源
    《Biomaterials Science》 |2018年第8期|共14页
  • 作者

    Chen Yu-li; Liu Feng-qiu; Guo Yuan; Cheng Juan; Yang Lu; Lu Min; Li Pan; Xu Jie; Yu Tao; Wang Zhi-gang; Cao Yang; Ran Hai-tao;

  • 作者单位

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Chongging Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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