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首页> 外文期刊>Biomaterials Science >Zinc ion coordination significantly improved the transfection efficiency of low molecular weight polyethylenimine
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Zinc ion coordination significantly improved the transfection efficiency of low molecular weight polyethylenimine

机译：锌离子协调显着提高了低分子量聚乙烯亚胺的转染效率

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摘要

Polycationic gene carriers are attracting increasing attention for their use as gene delivery systems. Herein, a novel and high-performance polycationic gene carrier (i.e., Zn-DPPA2) was constructed by introducing a dipicolylamine compound along with zinc ion coordination onto polyethylenimine (PEI1.8k) via Schiff base bonds. Zn-DPPA2 exhibited efficient transfection and negligible cytotoxicity. Zn-DPPA2/DNA complexes possessed significant endocytosis efficiency and excellent endosomal escape ability. Additionally, this polycaitionic gene carrier showed an excellent ability as an antiserum. The nanoscale size and good size stability ensured that Zn-DPPA2/DNA could accumulate in tumor tissue through the enhanced permeability and retention (EPR) effect. Moreover, Zn-DPPA2/DNA complexes exhibited efficient transfection in tumor tissue after intravenous injection. This strategy provided a new idea for polycationic gene carrier construction, which has prospects for widespread application in the field of gene therapy.
机译：聚阳离子基因载体因其作为基因递送系统而越来越关注。本文，通过将二维丙胺化合物与锌离子配位引入聚乙基亚胺（PEI1.8K）通过Schiff碱基键来构建新的和高性能聚酰基基因载体（即，Zn-DPPA2）。 Zn-DPPA2表现出高效的转染和可忽略的细胞毒性。 Zn-DPPA2 / DNA复合物具有显着的内吞作用效率和优异的内体逃逸能力。另外，该多条加入载体显示出作为抗血清的优异能力。纳米级尺寸和良好的尺寸稳定性确保Zn-DPPA2 / DNA通过增强的渗透率和保留（EPR）效应可以在肿瘤组织中积聚。此外，Zn-DPPA2 / DNA复合物在静脉注射后在肿瘤组织中表现出有效的转染。该策略为聚康复基因载体构建提供了一种新的思想，该载体载体构建具有广泛应用于基因治疗领域的前景。

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  • 来源
    《Biomaterials Science》 |2019年第4期|共13页
  • 作者

    Fang Huapan; Lin Lin; Chen Jie; Wu Jiayan; Tian Huayu; Chen Xuesi;

  • 作者单位

    Chinese Acad Sci Key Lab Polymer Ecomat Changchun Inst Appl Chem Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Key Lab Polymer Ecomat Changchun Inst Appl Chem Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Key Lab Polymer Ecomat Changchun Inst Appl Chem Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Key Lab Polymer Ecomat Changchun Inst Appl Chem Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Key Lab Polymer Ecomat Changchun Inst Appl Chem Changchun 130022 Jilin Peoples R China;

    Chinese Acad Sci Key Lab Polymer Ecomat Changchun Inst Appl Chem Changchun 130022 Jilin Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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