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首页> 外文期刊>Biomaterials Science >Smart wound dressing for infection monitoring and NIR-triggered antibacterial treatment
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Smart wound dressing for infection monitoring and NIR-triggered antibacterial treatment

机译：智能伤口敷料进行感染监测和先兆触发的抗菌治疗

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Wound infection is a major challenge in the clinic that greatly hinders the wound healing process. It is highly important to develop smart wound dressings that can sense bacterial infection at early stages and provide on-demand treatment. In this work, a smart hydrogel-based wound dressing capable of monitoring bacterial infection via a pH-responsive fluorescence resonance energy transfer (FRET) transition of Cyanine3 (Cy3) and Cyanine5 (Cy5) in a bacterial environment and providing on-demand treatment of infection via near infrared (NIR) light-triggered antibiotic release was developed. The smart hydrogel was prepared by physical crosslinking of polyvinyl alcohol (PVA) and an ultraviolet (UV)-cleavable polyprodrug (GS-Linker-MPEG), in which Cy3 and Cy5-modified silica nanoparticles (SNP-Cy3/Cy5) were loaded and acted as a pH-responsive fluorescent probe to detect bacterial infection based on the FRET effect between Cy3 and Cy5. Also, up-conversion nanoparticles (UCNP) were loaded into the hydrogels to cleave the UV-responsive GS-Linker-MPEG and achieve NIR-responsive release of GS in the bacterial environment. The in vitro studies proved that the smart hydrogels present good water absorption ability and excellent mechanical properties as well as good biocompatibility, which are necessary for their application in wound dressings. Moreover, the hydrogels showed obvious FRET transitions in both acidic buffer and bacteria solution. Upon irradiating the hydrogels with NIR light, UCNP were able to convert NIR light to UV light to trigger the release of GS from the hydrogels for antibacterial treatment. This research is expected to provide a new strategy for self-reporting and effective treatment of wound infection.
机译：伤口感染是临床的主要挑战，极大地阻碍了伤口愈合过程。开发智能伤口敷料非常重要，可以在早期阶段感测细菌感染并提供按需治疗。在这项工作中，一种能够通过Cyanine3（Cy3）和Cyanine5（Cy5）在细菌环境中的pH响应荧光共振能量转移（FRET）过渡并提供按需治疗方法开发了通过近红外线（NIR）触发抗生素释放的感染。通过聚乙烯醇（PVA）的物理交联制备智能水凝胶，紫外（UV）可切割的聚丙扣（GS-LINKER-MPEG），其中加载CY3和CY5改性二氧化硅纳米粒子（SNP-CY3 / CY5）用作pH响应荧光探针，以检测基于Cy3和Cy5之间的摩托效应的细菌感染。此外，将上转化纳米颗粒（UCNP）加载到水凝胶中，以切割UV响应性GS-LINKER-MPEG并在细菌环境中实现GS的NIR响应释放。体外研究证明，智能水凝胶具有良好的吸水能力和优异的机械性能以及良好的生物相容性，这对于它们在伤口敷料中的应用是必需的。此外，水凝胶在酸性缓冲液和细菌溶液中显示出明显的褶皱过渡。在用NIR光照射水凝胶时，UCNP能够将NIR光转化为UV光，以引发来自水凝胶的GS的释放以进行抗菌处理。预计这项研究将为自我报告和有效治疗伤口感染提供新的策略。

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