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首页> 外文期刊>Biomaterials Science >A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy
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A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy

机译：一种线粒体靶向抗癌的抗癌，深入渗透，用于增强协同声学和饥饿治疗

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Sonodynamic therapy (SDT), as an emerging technique, gives rise to reactive oxygen species (ROS)-induced apoptosis of tumor cells. However, nonselective enrichment and unsatisfactory penetration depth of sonosensitizers in tumor tissues limit its application. In this study, we synthesized core/shell (glucose oxidase (GOx) in the core/hematoporphyrin monomethyl ether (HMME) and IR780 in the shell) structured polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) with deep tumor penetration and mitochondrial targeting capability for synergistic sonodynamic and starvation therapy. After passing through the endothelial space of tumor vasculatures, by virtue of IR780, these NPs can selectively accumulate towards cancer cells/sites, especially in mitochondria and diffuse into deep tumour centres. Upon ultrasound (US) exposure, the overproduced ROS cause tumor cell apoptosis. Sonodynamic effects can be amplified by mitochondrial targeting because mitochondria are susceptible to ROS. GOx blocks glucose (energy) supply, further suppressing the growth of malignant tumors. This synergistic therapy exhibited a superb response to treatment (4.7-fold lower tumor growth in volume than the control group). In addition, these NPs also serve as excellent photoacoustic (PA)/fluorescent (FL) imaging contrast agents to simultaneously monitor and guide cancer therapy. This study paves a promising way to achieve an ideal strategy for cancer therapy.
机译：Sonodynamic Therapy（SDT）作为一种新兴技术，导致反应性氧（ROS） - 诱导肿瘤细胞的凋亡。然而，肿瘤组织中超声胶质剂的非选择性富集和不令人满意的渗透深度限制了其应用。在该研究中，我们在壳体/血液卟啉单甲基醚（HMME）和IR780中的核/壳（葡萄糖氧化酶（GOX）和壳中的IR780中合成）结构化的聚乳酸 - 共乙醇酸（PLGA）纳米颗粒（NPS），具有深层肿瘤渗透和线粒体靶向能力，适用于协同超声动力学和饥饿治疗。通过IR780的肿瘤血管内皮空间通过IR780，这些NPS可以选择性地积累朝向癌细胞/位点，特别是在线粒体中并扩散到深肿瘤中心。超声（美国）曝光后，过度屈服的ROS引起肿瘤细胞凋亡。可以通过线粒体靶向扩增奏效效应，因为线粒体易受ROS的影响。 Gox块葡萄糖（能量）供应，进一步抑制恶性肿瘤的生长。这种协同疗法表现出对治疗的一倍效应（比对照组的4.7倍的肿瘤生长4.7倍。此外，这些NP还用作优异的光声（PA）/荧光（FL）成像造影剂，以同时监测和引导癌症治疗。本研究铺平了一种有希望的方法来实现癌症治疗的理想策略。

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