...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials Science >Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications
【24h】

Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications

机译：利用层逐层组装技术设计用于平移应用中免疫调制的生物材料疫苗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The existence of challenging diseases such as cancers, HIV and Zika requires developing new vaccines that can generate tunable and robust immune responses against the diseases. Biomaterials-based techniques have been broadly explored for designing vaccines that can produce controllable and potent immunity. Among the existing biomaterials-based strategies, the layer-by-layer (LbL) assembly technique is remarkably attractive in vaccine design due to its unique features such as programmed and versatile cargo loading, cargo protection, co-delivery, juxtaposing of immune signals, etc. In this work, we reviewed the existing LbL-based vaccine design techniques for translational applications. Specifically, we discussed nanovaccines constructed by coating polyelectrolyte multilayers (PEMs) on nanoparticles, microcapsule vaccines assembled from PEMs, polyplex/complex vaccines condensed from charged materials and microneedle vaccines deposited with PEMs, highlighting the employment of these techniques to promote immunity against diseases ranging from cancers to infectious and autoimmune diseases (i.e., HIV, influenza, multiple sclerosis, etc.). Additionally, the review specifically emphasized using LbL-based vaccine technologies for tuning the cellular and molecular pathways, demonstrating the unique advantages presented by these vaccination strategies. These studies showed the versatility and potency of using LbL-based techniques for designing the next generation of biomaterials vaccines for translational purposes.
机译：存在挑战性疾病，如癌症，艾滋病毒和Zika需要开发新的疫苗，可以产生针对疾病的可调和鲁棒免疫反应。广泛探索了基于生物材料的技术，用于设计可以产生可控和有效免疫的疫苗。在现有的基于生物材料的策略中，由于其独特的特征，逐层（LBL）组装技术在疫苗设计中具有显着的疫苗设计，例如编程和多功能货物装载，货物保护，共同交付，免疫信号并置，免疫信号，在这项工作中，我们审查了用于平移应用的现有LBL的疫苗设计技术。具体地，我们讨论了通过在纳米颗粒上涂覆聚电解质多层（PEMS）构成的纳米虫，从PEMS组装的微胶囊疫苗，从带电材料和PEMS沉积的微针疫苗粘合，突出了这些技术的就业，促进免疫疾病癌症传染性和自身免疫疾病（即艾滋病毒，流感，多发性硬化等）。此外，使用基于LBL的疫苗技术特别强调的审查，用于调整细胞和分子途径，展示了这些疫苗接种策略所呈现的独特优势。这些研究表明，使用基于LBL的技术来设计下一代生物材料疫苗的多功能性和效力。

著录项

  • 来源
    《Biomaterials Science》 |2019年第3期|共18页
  • 作者

    Tang Tan; Weng Tujun; Jia Hongxing; Luo Sida; Xu Ye; Li Liuhe; Zhang Peipei;

  • 作者单位

    Beihang Univ Sch Mech Engn &

    Automat Dept Mat Proc &

    Controlling Beijing Peoples R China;

    Peoples Liberat Army Gen Hosp Affiliated Hosp 1 Dept Orthopaed Beijing Peoples R China;

    Beihang Univ Sch Mech Engn &

    Automat Dept Mat Proc &

    Controlling Beijing Peoples R China;

    Beihang Univ Sch Mech Engn &

    Automat Dept Mat Proc &

    Controlling Beijing Peoples R China;

    Beihang Univ Sch Mech Engn &

    Automat Dept Mat Proc &

    Controlling Beijing Peoples R China;

    Beihang Univ Sch Mech Engn &

    Automat Dept Mat Proc &

    Controlling Beijing Peoples R China;

    Beihang Univ Sch Mech Engn &

    Automat Dept Mat Proc &

    Controlling Beijing Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号