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首页> 外文期刊>Biomaterials Science >A self-adapting hydrogel based on chitosan/oxidized konjac glucomannan/AgNPs for repairing irregular wounds
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A self-adapting hydrogel based on chitosan/oxidized konjac glucomannan/AgNPs for repairing irregular wounds

机译：基于壳聚糖/氧化Konjac Glucomannan / AgNP的修复不规则伤口的自适应水凝胶

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摘要

Wound dressings play a critical role in the cutaneous healing process. The uncertainty of an injury leads to an irregular wound. However, incomplete contact between a general dressing and wound reduces the effectiveness of the dressing. Therefore, self-adapting hydrogels that are adhesive, injectable, and self-healable are being developed to efficiently treat irregular skin wounds. Here, we present an approach based on dynamic Schiff-base bond formation to prepare self-adapting hydrogel dressings that automatically adapt to irregular wounds under natural conditions and sustain total contact with the injured site. Spectroscopic investigations suggested the formation of dynamic covalent Schiff-base bonds, which are closely associated with the rapid formation of the hydrogel, between the aldehyde groups of oxidized konjac glucomannan and amine groups in the backbone of protonated chitosan and protonated tranexamic acid. Rheological analysis confirmed the self-healing property of the hydrogel, that is, the recovery of the broken hydrogel network. Histological analysis indicated that this self-adapting hydrogel provides a clear advantage over the commercial hydrogel dressing (AquacelAg (TM)) in the in vivo wound-healing process. Our rapidly gelating hydrogel formulations with self-healing ability, tissue adhesiveness, and antibacterial activity are very promising self-adapting biomaterials for repairing irregular wounds.
机译：伤口敷料在皮肤愈合过程中发挥着关键作用。损伤的不确定性导致伤口不规则。然而，一般敷料和伤口之间的不完全接触降低了敷料的有效性。因此，正在开发出粘合剂，可注射和自我渗透和自我渗透的自适应水凝胶以有效地治疗不规则的皮肤伤口。在这里，我们提出了一种基于动态席夫基础键组的方法，以制备自适应水凝胶敷料，该敷料自然适应自然条件下的不规则伤口，并维持与受伤部位的总接触。光谱研究表明，形成动态共价席夫基键，其与水凝胶的快速形成密切相关，在质子化壳聚糖和质子化的癸酸骨干中的氧化康康甘甘蓝和胺基团之间的醛基之间。流变分析证实了水凝胶的自愈性，即破碎的水凝胶网络的回收率。组织学分析表明，这种自适应水凝胶在体内伤口愈合过程中，在商业水凝胶敷料（AquaceLag（TM））上提供了明显的优势。我们的快速凝胶水凝胶配方具有自我愈合能力，组织粘合性和抗菌活性非常有前途的自适应生物材料，用于修复不规则的伤口。

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