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首页> 外文期刊>Biomaterials Science >Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging
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Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging

机译：多功能治疗纳米系统，使三重刺激响应药物释放的光热化疗组合治疗用磁共振成像

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摘要

Theranostic nanosystems are emerging as a promising approach for controlled drug delivery, diagnosis and multimodal therapeutics. Herein, a multifunctional theranostic nanoplatform is reported for photothermal-chemo combination therapy functioned with magnetic and thermal imaging. Hyaluronic acid (HA) coated Fe3O4@polydopamine nanoparticles equipped with redox-sensitive disulfide linkers have been subsequently deposited with an anticancer drug, doxorubicin (DOX) (termed as FPCH-DOX NPs). These nanocomposites possess an average diameter of 120 nm, a saturation magnetization of 28.5 emu g(-1), DOX loading capacity of 7.13% and a transverse relaxation rate of 171.76 mM(-1) s(-1). The drug release could be triggered by pH, glutathione (GSH) concentration and light irradiation. Prussian blue staining and confocal microscopy demonstrate that these nanoplatforms have improved biocompatibility and cellular uptake in CD44-positive HeLa cell lines rather than in CD44-negative NIH 3T3 normal cell lines. In vitro evaluations demonstrate that the combination therapy of FPCH-DOX NPs lowers the cell viability to 16.2%, less than that of individual chemotherapy (55.3%) or PTT (52.1%). In vivo MRI indicates that the tumor accumulation of FPCH-DOX NPs provides enhanced MRI contrast, and in vivo thermal imaging verified their localized photothermal conversion effect in tumor tissues. Importantly, FPCH-DOX NPs present remarkable anti-tumor efficacy by photothermal-chemo combination therapy. H&E and Ki67 staining tests show obvious necrosis and weak cell proliferation at the region of the tumor. Thus, FPCH-DOX NPs are promising multifunctional nanoplatforms for highly effective cancer theranostics.
机译：Theranostic Nanosystems正在成为受控药物递送，诊断和多式化治疗方法的有希望的方法。这里，报道了一种多官能的治疗纳米纳薄型，用于用磁性和热成像功能起作用的光热化疗组合疗法。透明质酸（HA）涂覆的Fe3O4（Ha）纳米胺纳米胺纳米粒子随后用抗癌药物，多柔霉素（DOX）（称为FPCH-DOX NPS）沉积。这些纳米复合材料具有120nm的平均直径，饱和磁化为28.5 emu g（-1），dox负载容量为7.13％，横向松弛率为171.76mm（-1）（-1）。药物释放可以通过pH，谷胱甘肽（GSH）浓度和光辐射触发。普鲁士蓝染色和共聚焦显微镜证明这些纳米纳薄形成具有改善CD44阳性HeLa细胞系中的生物相容性和细胞摄取，而不是CD44阴性NIH 3T3正常细胞系。体外评估表明，FPCH-DOX NP的组合治疗将细胞活力降低至16.2％，小于单个化疗（55.3％）或PTT（52.1％）。在体内MRI表明FPCH-DOX NPS的肿瘤积累提供增强的MRI对比度，并且体内热成像验证了它们在肿瘤组织中的局部光热转化效应。重要的是，FPCH-DOX NPS通过光热化疗组合疗法表现出显着的抗肿瘤效果。 H＆E和KI67染色试验显示肿瘤区域明显的坏死和细胞薄弱细胞增殖。因此，FPCH-DOX NPS是对高效癌症治疗学的多功能纳米纳薄形成。

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