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首页> 外文期刊>Biomaterials Science >Preparation and evaluation of PAMAM dendrimer-based polymer gels physically cross-linked by hydrogen bonding
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Preparation and evaluation of PAMAM dendrimer-based polymer gels physically cross-linked by hydrogen bonding

机译：用氢键合理交联的PAMAM树枝状聚合物的聚合物凝胶的制备与评价

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摘要

Polymer gels can be classified as chemical and physical gels, depending on the type of cross-link. Physical gels usually form by physical cross-linking, such as hydrogen bonding, van der Waals and/or p-p interactions, which can avoid the use of additional cross-linking agents. Polyamidoamine (PAMAM) dendrimers possess abundant active groups on their surfaces. Modified dendrimers have been used as versatile linkers in some projects. In this work, polymer gels composed of PAMAM dendrimers without any covalent bonding cross-linking agents were prepared. The number of amino groups and ester groups on the surface of the dendrimers was precisely regulated to help form hydrogen bonds between adjacent dendrimers. The prepared dendrimer-based polymer gels retain the properties of PAMAM dendrimers such as antibacterial properties, and the unique structures make the gels exhibit high compressive strengths but relatively low tensile strengths. Interestingly, the prepared gels show good anti-inflammatory properties in acute inflammation models of mice with ear edema. The inflammatory inhibition rate and hematoxylin-eosin (H&E) staining method were used to confirm the anti-inflammatory effect. This present study demonstrates that the dendrimer-based polymer gels achieved through hydrogen bonding could be a versatile platform for tissue engineering.
机译：根据交联的类型，聚合物凝胶可以被归类为化学和物理凝胶。物理凝胶通常通过物理交联形成，例如氢键，范德华和/或P-P相互作用，这可以避免使用额外的交联剂。聚酰胺胺（PAMAM）树枝状大分子在其表面上具有丰富的活性组。修改的树枝状大分子已被用作某些项目中的多功能接头。在这项工作中，制备由没有任何共价键合的交联剂的PAMAM树枝状聚合物组成的聚合物凝胶。精确调节树枝状花叶表面上的氨基和酯基的数量，以帮助在相邻的树枝状大分子之间形成氢键。制备的树突式的聚合物凝胶保留了PAMAM树枝状大分子的性质，例如抗菌性能，并且独特的结构使凝胶具有高抗压强度，但抗拉强度相对较低。有趣的是，制备的凝胶在耳朵水肿的小鼠急性炎症模型中显示出良好的抗炎性质。使用炎症抑制率和苏木精 - 曙红（H＆E）染色方法来证实抗炎作用。本研究表明，通过氢键实现的树枝状聚合物的聚合物凝胶可以是组织工程的多功能平台。

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  • 来源
    《Biomaterials Science》 |2019年第9期|共8页
  • 作者

    Cong Hailin; Zhou Liping; Meng Qingye; Zhang Yixin; Yu Bing; Shen Youqing; Hu Hao;

  • 作者单位

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

    Qingdao Univ Coll Mat Sci &

    Engn Inst Biomed Mat &

    Engn Qingdao 266071 Shandong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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