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首页> 外文期刊>Biomaterials Science >Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy
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Melanin-like nanoparticles loaded with an angiotensin antagonist for an improved photothermal cancer therapy

机译：黑色素样纳米颗粒装有血管紧张素拮抗剂，用于改善的光热癌症治疗

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An abnormal tumor growth induces solid stress in tumors, thus reducing blood perfusion. As a result, the impaired blood perfusion, with dense interstitial matrix in tumors significantly reduces the penetration and efficacy of nanotherapeutics. In this study, we have developed a losartan-loaded polydopamine nanoparticle (PLST) for the enhanced delivery of nanoparticles to tumors and improved photothermal cancer therapy. Losartan, an angiotensin inhibitor, is also able to alleviate the solid stress in tumors. It was laden on polydopamine nanoparticles via pi-pi stacking and was released upon tumor extracellular acidity. PLST reduced collagen production in vitro along with the lowered expression of profibrotic factors of TGF-beta 1, CCN2, and TIMP-1. The in vivo studies reveal that PLST reduced solid stress in tumors, and the amount of PLST accumulated in tumors was enhanced. The efficiency of the photothermal ablation of tumors was significantly enhanced by using PLST.
机译：异常肿瘤生长诱导肿瘤中的固体胁迫，从而减少血液灌注。 因此，血液灌注受损，肿瘤中致密的间质基质显着降低了纳米治疗剂的渗透性和功效。 在这项研究中，我们开发了一种Losartan加载的多德莫胺纳米粒子（PLST），用于增强纳米颗粒与肿瘤和改善的光热癌疗法的递送。 Losartan，血管紧张素抑制剂，也能够缓解肿瘤中的固体胁迫。 通过PI-PI堆叠堆积在聚二胺纳米粒子上，并在肿瘤细胞外酸度释放。 PLST在体外降低胶原蛋白的生产，随着TGF-β1，CCN2和TIMP-1的降低表达。 体内研究表明，巨大的肿瘤中的固体胁迫降低，肿瘤中积累的庞大的量得到了增强。 使用普尔斯特显着增强了肿瘤的光热消融的效率。

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