Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes

Hou Changshun; Yi Bo; Jiang Jieke; Chang Yung-Fu; Yao Xi

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Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes

机译：最新的疫苗交付系统：通过各种路线在管理时由多种纳米材料引发的强大免疫力

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In this review, we summarize the recent design strategies (2015-present) of nanomaterial-based vaccine delivery systems via multiple routes to induce robust protective immunity. The selected topics are focused on the novel design strategies of nanomaterial carriers for vaccine delivery. Inspired by recent advances, we also briefly introduce the emerging administration routes that may give rise to synergistic immune effects with advanced delivery systems. Ultimately, we present the existing challenges and survey the prospective development of various nanoparticle vaccine delivery systems.

机译：在本文中，我们通过多种路线总结了最近基于纳米材料的疫苗递送系统的设计策略（2015-展示），以诱导强大的保护性免疫。所选主题专注于纳米材料携带者的新颖设计策略，用于疫苗递送。灵感来自最近的进展，我们还简要介绍了可能导致与先进交付系统产生协同免疫效应的新兴的行政途径。最终，我们展示了现有的挑战和调查各种纳米粒子疫苗递送系统的前瞻性发展。

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来源
《Biomaterials Science》 |2019年第3期|共14页
作者
Hou Changshun; Yi Bo; Jiang Jieke; Chang Yung-Fu; Yao Xi;
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作者单位

City Univ Hong Kong Dept Biomed Sci Kowloon Tat Chee Ave Hong Kong Peoples R China;

City Univ Hong Kong Dept Biomed Sci Kowloon Tat Chee Ave Hong Kong Peoples R China;

City Univ Hong Kong Dept Biomed Sci Kowloon Tat Chee Ave Hong Kong Peoples R China;

Cornell Univ Coll Vet Med Dept Populat Med &

Diagnost Sci Ithaca NY 14853 USA;

City Univ Hong Kong Dept Biomed Sci Kowloon Tat Chee Ave Hong Kong Peoples R China;

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正文语种 eng
中图分类分子生物学;
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1. Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes [J] . Hou Changshun, Yi Bo, Jiang Jieke, Biomaterials Science . 2019,第3期

机译：最新的疫苗交付系统：通过各种路线在管理时由多种纳米材料引发的强大免疫力
2. Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses [J] . Li P., Luo Z., Liu P., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2013,第3期

机译：可生物还原的藻酸盐-聚（亚乙基亚胺）纳米凝胶作为抗原传递系统，可强有力地增强疫苗引起的体液和细胞免疫反应
3. Intravaginal immunization using a novel antigen delivery device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses [J] . PF McKay, JF Mann, A Pattani, Retrovirology . 2012,第S2期

机译：使用新型抗原递送装置进行阴道内免疫可引发强大的疫苗抗原特异性全身和粘膜体液免疫反应
4. The Multiepitope Anticysticercosis Vaccine from Laboratory to the Field: Novel Delivery Systems and Alternative Routes for Vaccine Administration [C] . E. Sciutto, J. Morales, G- Rosas, International Congress of Parasitology . 2006

机译：从实验室到现场的多孔雀病毒疫苗疫苗：新型递送系统和疫苗管理替代路线
5. Development of Listeria monocytogenes as a vaccine vector for the delivery of a model antigen to the immune system. [D] . Ikonomidis, Georgios I. 1996

机译：单核细胞增生李斯特菌疫苗的开发，用于将模型抗原递送至免疫系统。
6. Intravaginal immunization using a novel antigen delivery device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses [O] . PF McKay, JF Mann, A Pattani, 2012

机译：使用新型抗原递送装置进行阴道内免疫可引发强大的疫苗抗原特异性全身和粘膜体液免疫反应
7. Intravaginal immunization using a novel antigen delivery device elicits robust vaccine antigen-specific systemic and mucosal humoral immune responses [O] . McKay PF, Mann JF, Pattani A, 2012

机译：使用新型抗原递送装置进行阴道内免疫可引发强大的疫苗抗原特异性全身和粘膜体液免疫反应
8. Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. [R] . Dupuy, L. C., Richards, M. J., Livingston, B. D., 2016

机译：通过肌内电穿孔提供的多剂甲病毒DNa疫苗在小鼠和家兔中引发健壮和耐久的病毒特异性免疫应答，并完全保护小鼠免受致命的委内瑞拉，西方和东方马脑炎病毒气溶胶挑战。

Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes

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