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首页> 外文期刊>Biomaterials Science >NIR-cleavable drug adducts of gold nanostars for overcoming multidrug-resistant tumors
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NIR-cleavable drug adducts of gold nanostars for overcoming multidrug-resistant tumors

机译：用于克服多药肿瘤的金纳米瘤的NIR可切割的药物加合物

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摘要

An aptamer-conjugated gold nanostar (dsDDA-AuNS) has been developed for targeting nucleolin present in both tumor cells and tumor vasculature for conducting a drug-resistant cancer therapy. AuNS with its strong absorption in the near-infrared (NIR) region was assembled with a layer of the anti-nucleolin aptamer AS1411. An anticancer drug, namely doxorubicin (DOX), was specifically conjugated on deoxyguanosine residues employing heat and acid labile methylene linkages. In response to NIR irradiation, dsDDA-AuNS allowed on-demand therapeutics. AS1411 played an active role in drug cargo-nucleus interactions, enhancing drug accumulation in the nuclei of drug-resistant breast cancer cells. The intravenous injection of dsDDA-AuNS allowed higher drug accumulation in drug-resistant tumors over naked drugs, leading to greater therapeutic efficacy even at a 54-fold less equivalent drug dose. The in vivo triggered release of DOX from dsDDA-AuNS was achieved by NIR irradiation, resulting in simultaneous photothermal and chemotherapeutic actions, yielding superior tumor growth inhibition than those obtained from either type of monotherapy for overcoming drug resistance in cancers.
机译：已经开发了一种适体缀合的金纳盘（DSDDA-AUN），用于靶向肿瘤细胞和肿瘤脉管系统中存在的核仁，以进行耐药性癌症治疗。具有其在近红外（NIR）区域的强吸收的肛门，用一层抗核苷酸适体AS1411组装。抗癌药物即多柔比星（DOX），在使用热和酸不稳定亚甲基键的脱氧核苷酸残基上特别缀合。响应NIR辐照，DSDDA-AUNS允许按需治疗。 AS1411在药物货物核相互作用中发挥了积极作用，增强了耐药乳腺癌细胞核中的药物积累。静脉注射DSDDA-AUNs在裸体药物上允许耐药肿瘤的耐药肿瘤较高，即使在54倍的当量药物剂量下也导致更大的治疗效果。通过NIR辐射实现了来自DSDDA-AUN的DOX的体内触发释放，导致同时的光热和化学治疗动作，产生优于肿瘤生长抑制，而不是从任一种克服癌症耐药性的单一药物抗药性。

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