...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials Science >Applying macromolecular crowding to 3D bioprinting: fabrication of 3D hierarchical porous collagen-based hydrogel constructs
【24h】

Applying macromolecular crowding to 3D bioprinting: fabrication of 3D hierarchical porous collagen-based hydrogel constructs

机译：将大分子拥挤施加到3D BioPlinting：3D层次胶原基水凝胶构建体的制作

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Native tissues and/or organs possess complex hierarchical porous structures that confer highly-specific cellular functions. Despite advances in fabrication processes, it is still very challenging to emulate the hierarchical porous collagen architecture found in most native tissues. Hence, the ability to recreate such hierarchical porous structures would result in biomimetic tissue-engineered constructs. Here, a single-step drop-on-demand (DOD) bioprinting strategy is proposed to fabricate hierarchical porous collagen-based hydrogels. Printable macromolecule-based bio-inks (polyvinylpyrrolidone, PVP) have been developed and printed in a DOD manner to manipulate the porosity within the multi-layered collagen-based hydrogels by altering the collagen fibrillogenesis process. The experimental results have indicated that hierarchical porous collagen structures could be achieved by controlling the number of macromolecule-based bio-ink droplets printed on each printed collagen layer. This facile single-step bioprinting process could be useful for the structural design of collagen-based hydrogels for various tissue engineering applications.
机译：本机组织和/或器官具有复杂的分层多孔结构，其赋予高度特异性的细胞功能。尽管制造过程中的进步，但在大多数本地组织中发现发现的分层多孔胶原型建筑仍然非常具有挑战性。因此，重现这种分层多孔结构的能力将导致仿生化组织工程构建体。这里，提出了一种单步滴落性（DOD）生物监测策略，用于制造分层多孔胶原基水凝胶。通过改变胶原纤维生成过程，已经开发并印刷了基于型大分子的生物油墨（聚乙烯吡咯烷酮，PVP）并印刷以操纵多层胶原基水凝胶内的孔隙率。实验结果表明，通过控制印刷在每个印刷的胶原层上印刷的基于大分子的生物墨滴的数量，可以实现分层多孔胶原结构。这种容易的单步生物印刷工艺可用于各种组织工程应用的基于胶原基水凝胶的结构设计。

著录项

  • 来源
    《Biomaterials Science》 |2018年第3期|共13页
  • 作者

    Ng Wei Long; Goh Min Hao; Yeong Wai Yee; Naing May Win;

  • 作者单位

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn SC3DP 50 Nanyang Ave Singapore 639798 Singapore;

    ASTAR Singapore Inst Mfg Technol SIMTech Biomfg Programme 71 Nanyang Dr Singapore 638075 Singapore;

    Nanyang Technol Univ Sch Mech &

    Aerosp Engn SC3DP 50 Nanyang Ave Singapore 639798 Singapore;

    ASTAR Singapore Inst Mfg Technol SIMTech Biomfg Programme 71 Nanyang Dr Singapore 638075 Singapore;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号