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Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)

机译:操纵肿瘤缺氧对增强的光动力治疗(PDT)

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摘要

Photodynamic therapy (PDT) is considered a promising approach for the treatment of cancer and is achieved via the photosensitizer (PS)- mediated incomplete reduction of oxygen upon light irradiation, which generates high levels of reactive oxygen species (ROS) to induce potent vascular damage and to directly kill tumor cells. However, there is an undesirable impediment with this approach in that tumor tissues generally suffer from serious hypoxia, which significantly affects the efficiency of PDT. Additionally, PDT that consumes oxygen will further aggravate tumor hypoxia, thus potentially leading to multiple undesirable consequences, such as angiogenesis, tumor invasiveness, and tumor metastasis. This mini-review provides a comprehensive overview of the recent research progress on overcoming or utilizing tumor hypoxia to enhance the therapeutic efficacy of PDT.
机译:光动力治疗(PDT)被认为是治疗癌症的有希望的方法,通过光敏剂(PS)介导的氧气在光照射时介导的不完全减少,从而产生高水平的活性氧(ROS),以诱导有效的血管损伤 并直接杀死肿瘤细胞。 然而,这种方法存在不良障碍,因为这种方法在肿瘤组织通常遭受严重的缺氧,这显着影响了PDT的效率。 此外,消耗氧气的PDT将进一步加剧肿瘤缺氧,因此可能导致多种不良后果,例如血管生成,肿瘤侵袭性和肿瘤转移。 该迷你审查提供了最近克服或利用肿瘤缺氧的研究进展的全面概述,以提高PDT的治疗效果。

著录项

  • 来源
    《Biomaterials Science》 |2017年第8期|共12页
  • 作者单位

    Soochow Univ Inst Funct Nano &

    Soft Mat FUNSOM Jiangsu Key Lab Carbon Based Funct Mat &

    Devices Suzhou 215123 Peoples R China;

    Soochow Univ Inst Funct Nano &

    Soft Mat FUNSOM Jiangsu Key Lab Carbon Based Funct Mat &

    Devices Suzhou 215123 Peoples R China;

    Tongji Univ Shanghai Pulm Hosp Sch Med Dept Thorac Surg Shanghai Peoples R China;

    Soochow Univ Inst Funct Nano &

    Soft Mat FUNSOM Jiangsu Key Lab Carbon Based Funct Mat &

    Devices Suzhou 215123 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

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