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首页> 外文期刊>Biomaterials Science >Surgical suture releasing macrophage-targeted drug-loaded nanoparticles for an enhanced anti-inflammatory effect
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Surgical suture releasing macrophage-targeted drug-loaded nanoparticles for an enhanced anti-inflammatory effect

机译：手术缝合线释放巨噬细胞靶向药物负载纳米颗粒，用于增强的抗炎作用

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摘要

A surgical suture is a medical device to close the wound site of skin and organs but excessive inflammation surrounding the suture can disrupt the wound healing process. Although post-operative prescription of anti-inflammatory drugs is used to manage the inflammation, the need for local drug delivery systems has been rising because of low bioavailability and fast clearance of drugs. In this work, we proposed a new strategy for a local anti-inflammatory device by incorporating macrophage-targeted anti-inflammatory nanoparticles into the suture. For macrophage-targeted anti-inflammatory nanoparticles, poly(lactic-coglycolic) nanoparticles were loaded with anti-inflammatory drug diclofenac and decorated with polyethylene glycol and macrophage-targeting ligand mannose. These anti-inflammatory nanoparticles released diclofenac sustainably, and targeted activated macrophages efficiently. After nanoparticle optimization, a suture was coated with multiple layers of macrophage-targeted anti-inflammatory nanoparticles using a dip coating process. The suture releasing macrophage-targeted anti-inflammatory nanoparticles showed an enhanced anti-inflammatory effect in both macrophage culture and excisional wound healing animal models compared to a free drug molecule-coated suture. These results suggest that anti-inflammatory nanoparticle-coated sutures have great potential as an effective local delivery system to reduce inflammation and pain at the wound site.
机译：手术缝合线是一种闭合皮肤和器官的伤口部位的医疗装置，但围绕缝合线的过度炎症会破坏伤口愈合过程。虽然抗炎药的后术后处方用于管理炎症，但由于较低的生物利用度和药物的快速清除，对当地药物递送系统的需求一直在上升。在这项工作中，我们通过将巨噬细胞靶向的抗炎纳米颗粒掺入缝合线中，提出了局部抗炎装置的新策略。对于巨噬细胞靶向抗炎纳米颗粒，将聚（乳酸 - 果酱）纳米颗粒加载抗炎药DICLOFENAC，用聚乙二醇和巨噬细胞靶向配体甘露糖装饰。这些抗炎纳米颗粒可持续地释放Diclofenac，有效地靶向活化的巨噬细胞。纳米颗粒优化后，使用浸涂方法用多层巨噬细胞靶向抗炎纳米颗粒涂覆缝合线。释放巨噬细胞靶向抗炎纳米粒子的缝合线在巨噬细胞培养和切除伤口愈合动物模型中表现出增强的抗炎作用，与游离药物涂覆的缝合线相比。这些结果表明，抗炎纳米粒子涂层缝合线具有巨大的局部局部递送系统，以减少伤口部位的炎症和疼痛。

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  • 来源
    《Biomaterials Science》 |2017年第8期|共8页
  • 作者

    Kim Hansol; Kim Byung Hwi; Huh Beom Kang; Yoo Yeon Chun; Heo Chan Yeong; Choy Young Bin; Park Ji-Ho;

  • 作者单位

    Korea Adv Inst Sci &

    Technol Dept Bio &

    Brain Engn Daejeon 34141 South Korea;

    Seoul Natl Univ Coll Med Dept Biomed Engn Seoul 03087 South Korea;

    Seoul Natl Univ Coll Engn Interdisciplinary Program Bioengn Seoul 08826 South Korea;

    Metabiomed Co Ltd Res Ctr Cheongju 28161 South Korea;

    Seoul Natl Univ Coll Med Dept Plast &

    Reconstruct Surg Seoul 03087 South Korea;

    Seoul Natl Univ Coll Med Dept Biomed Engn Seoul 03087 South Korea;

    Korea Adv Inst Sci &

    Technol Dept Bio &

    Brain Engn Daejeon 34141 South Korea;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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