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首页> 外文期刊>Biomaterials Science >Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing
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Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing

机译：盐酸盐酸盐酸盐通过石墨烯氧化物负载：优异的抗菌平台，具有联系和剥离杀灭的协同效应

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摘要

Titanium and its alloys have been widely used in orthopedic and dental implants because of their excellent properties. However, implant failures still occur due to implant-associated bacterial infections. Therefore, proper surface modification of titanium and its alloys is necessary. In this work, commercial pure titanium plates were modified with graphene oxide (GO) which was used to load minocycline hydrochloride. Gram-positive Staphylococcus aureus (S. aureus) and Streptococcus mutans (S. mutans) and Gram-negative Escherichia coli (E. coli) were used to investigate the antibacterial activity of the samples. Human gingival fibroblast (HGF) cells were applied to assess the cytocompatibility of the various samples. To investigate cell adhesion and cell surface coverage in the presence of bacteria, the coculture of HGF cells and S. aureus was performed. The results indicated that the GO-modified titanium surface could inhibit the growth of the bacteria which had direct contact with GO, while it could not affect the bacteria without direct contact of GO. Minocycline hydrochloride on the GO-modified titanium surface (M@GO-Ti) showed a slow release behavior and exhibited excellent antibacterial activity with the synergistic effect of contact-killing and release-killing by GO and minocycline hydrochloride, respectively. In the coculture process with the presence of S. aureus, HGF cells on M@GO-Ti demonstrated the best cell viability and cell surface coverage among all the samples.
机译：钛及其合金已广泛用于矫形和牙科植入物，因为它们具有优异的性能。然而，由于植入物相关的细菌感染，植入失败仍然发生。因此，需要适当的钛和合金的表面改性。在这项工作中，用石墨烯（GO）改性商业纯钛板，其用于称为盐酸米诺环素盐酸盐。使用革兰氏阳性葡萄球菌金黄色葡萄球菌（金黄色葡萄球菌）和链球菌（S. mutans）和革兰氏阴性大肠杆菌（大肠杆菌）来研究样品的抗菌活性。施用人牙龈成纤维细胞（HGF）细胞以评估各种样品的细胞织组织。为了在细菌存在下研究细胞粘附和细胞表面覆盖，进行HGF细胞和金黄色葡萄球菌的共络。结果表明，Go-Demified钛表面可以抑制与Go直接接触的细菌的生长，而不会导致Go直接接触的细菌。盐酸盐酸盐酸盐在去修饰的钛表面（M @ Go-Ti）上显示出缓慢的释放行为，并分别表现出优异的抗菌活性，分别具有接触和脱氯化盐的接触和剥离杀灭的协同效应。在具有S.UUREUS的存在的共培养过程中，M @ GO-TI上的HGF细胞显示了所有样品中最好的细胞活力和细胞表面覆盖。

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  • 来源
    《Biomaterials Science》 |2018年第2期|共10页
  • 作者

    Qian Wenhao; Qiu Jiajun; Su Jiansheng; Liu Xuanyong;

  • 作者单位

    Tongji Univ Sch Stomatol Shanghai Engn Res Ctr Tooth Restorat &

    Regenerat Dept Prosthodont Shanghai 200072 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram &

    Superfine Shanghai 200050 Peoples R China;

    Tongji Univ Sch Stomatol Shanghai Engn Res Ctr Tooth Restorat &

    Regenerat Dept Prosthodont Shanghai 200072 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram &

    Superfine Shanghai 200050 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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