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Dendritic phospholipid-based drug delivery systems

机译：树突磷脂基药物递送系统

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摘要

A class of new dendritic phospholipid compounds with different hydrophilic dendritic poly(L-lysine) peripheries from generations 1 (G1) to 3 (G3) (DPL-1 to DPL-3) were synthesised and nano-drug delivery systems based on these compounds were prepared (DPN-2 and DPN-3). DPL-1 couldn't self-assemble into nanocarriers. The size, TEM image, and the CD spectrum of DPN-2 and DPN-3 were experimentally examined. The effect of the peripheral structure of dendritic phospholipid-based nanocarriers on their biological performance and drug delivery efficiency was studied. In vitro cytotoxicity studies demonstrated that the DOX-loaded DPN-3 shows higher cytotoxicity against 4T1 cells and BGC823 cells than DPN-2. DOX-loaded DPN-3 also showed excellent behaviours in cell internalization and 4T1 multicellular spheroid penetration. The composition of the hydrophilic block in dendritic phospholipids affected the self-assembly behaviour, properties and delivery efficiency of the formed nanocarriers. This work will be helpful for building drug delivery systems with characteristics of high delivery efficiency and low cytotoxicity for clinical applications.
机译：一类具有不同亲水性树枝状聚（L-赖氨酸）外周的新的树突磷脂化合物，合成来自几代1（G1）至3（G3）（DPL-1至DPL-3），基于这些化合物的纳米药物递送系统制备（DPN-2和DPN-3）。 DPL-1无法自组装成纳米载波。实验检查DPN-2和DPN-3的尺寸，TEM图像和CD谱。研究了树突磷脂基纳米载体外周结构对其生物性能和药物递送效率的影响。体外细胞毒性研究表明，DOX加载的DPN-3对4T1细胞和BGC823细胞的细胞毒性高于DPN-2。 Dox加载的DPN-3还显示了细胞内化和4T1多细胞球体渗透的优异行为。树突磷脂中亲水嵌段的组成影响了形成纳米载体的自组装行为，性质和递送效率。这项工作将有助于构建具有高输送效率和低细胞毒性的药物递送系统，用于临床应用。

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  • 来源
    《Biomaterials Science》 |2018年第4期|共5页
  • 作者

    Jiang Lei; Chen Weizhi; Zhou Sensen; Li Cheng; Zhang Xiaoke; Wu Wei; Jiang Xiqun;

  • 作者单位

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

    Nanjing Univ Coll Chem &

    Chem Engn MOE Key Lab High Performance Polymer Mat &

    Techno Nanjing 210093 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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