Interaction of cells with patterned reactors

Zhu Chuntao; Taipaleenmaki Essi M.; Zhang Yan; Han Xiaojun; Stadler Brigitte

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Interaction of cells with patterned reactors

机译：细胞与图案反应器的相互作用

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Surface coatings that allow externally controlled interaction with cells are of interested for diverse biomedical applications. We fabricated particle patterns and assessed the interaction of these substrates with endothelial cells and hepatocytes. The particles were turned into subcompartmentalized reactors by immobilizing glucose oxidase loaded liposomes sandwiched between polymer layers. The reactor activities depending on the number of liposome deposition steps were confirmed in solution and on patterned surfaces. Finally, reduced viability of hepatocytes adhering to the reactor patterned surfaces in the presence of glucose was observed due to the local production of hydrogen peroxide. This first report on patterned reactors in combination with cells opens up vast opportunities to assemble interactive nanobiointerfaces.

机译：允许与细胞外部控制相互作用的表面涂层对各种生物医学应用感兴趣。我们制造了粒子图案并评估了这些基材与内皮细胞和肝细胞的相互作用。通过固定夹层夹在聚合物层之间的葡萄糖氧化酶负载脂质体，将颗粒转化为子组分化反应器。取决于脂质体沉积步骤的数量的反应器活性在溶液和图案化表面上得到证实。最后，由于局部产生了过氧化氢，观察到粘附在葡萄糖存在下粘附在葡萄糖存在下的反应器图案化表面的可存活率。在与细胞组合的图案反应器上的第一次报告为组装交互式纳米侵入件开辟了巨大的机会。

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来源
《Biomaterials Science》 |2018年第4期|共10页
作者
Zhu Chuntao; Taipaleenmaki Essi M.; Zhang Yan; Han Xiaojun; Stadler Brigitte;
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作者单位

Harbin Inst Technol Sch Chem &

Chem Engn State Key Lab Urban Water Resource &

Environm 92 West Da Zhi St Harbin 150001 Heilongjiang Peoples R China;

Aarhus Univ Interdisciplinary Nanosci Ctr iNANO Gustav Wieds Vej 14 DK-8000 Aarhus Denmark;

Aarhus Univ Interdisciplinary Nanosci Ctr iNANO Gustav Wieds Vej 14 DK-8000 Aarhus Denmark;

Harbin Inst Technol Sch Chem &

Chem Engn State Key Lab Urban Water Resource &

Environm 92 West Da Zhi St Harbin 150001 Heilongjiang Peoples R China;

Aarhus Univ Interdisciplinary Nanosci Ctr iNANO Gustav Wieds Vej 14 DK-8000 Aarhus Denmark;

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正文语种 eng
中图分类分子生物学;
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1. Interaction of cells with patterned reactors [J] . Zhu Chuntao, Taipaleenmaki Essi M., Zhang Yan, Biomaterials Science . 2018,第4期

机译：细胞与图案反应器的相互作用
2. Cell patterning without chemical surface modification: Cell-cell interactions between printed bovine aortic endothelial cells (BAEC) on a homogeneous cell-adherent hydrogel [J] . Chen CY, Barron JA, Ringeisen BR Applied Surface Science . 2006,第24期

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3. Patterning Mammalian Cells for Modeling Three Types of Naturally Occurring Cell-Cell Interactions [J] . Zhenling Chen, Yong Li, Wenwen Liu Angewandte Chemie . 2009,第44期

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Interaction of cells with patterned reactors

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