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Acellular biomaterial strategies for endodontic regeneration

机译：牙髓再生的无细胞生物材料策略

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摘要

Dental decay is treated by removing infected dental tissues such as dentine and restoring the tooth with a material. However, the vast majority of these materials have been designed to be mechanically robust and bioinert, whereas the potential regenerative properties of a biomaterial have not been considered. In endodontics for example, materials are used to seal the pulp cavity to avoid bacterial colonisation of the tooth and prevent further infection. While these treatments are effective in the short term, many of these materials have not been designed to interface with the pulp tissue in a biocompatible manner and are often cytotoxic. This can lead to less favourable long-term outcomes such as devitalisation of the tooth via root-canal therapy or extraction of the tooth. Clinical outcomes could be improved if regenerative approaches were followed whereby the biology of the tooth is engineered for repair and regeneration often with the support of a biomaterial. Within these, acellular or cell homing approaches are particularly interesting, as some regulatory hurdles associated with cellular therapies could be circumvented which may aid their clinical translation. In this review, we highlight progress in regenerative dentistry and focus on exciting developments using acellular biomaterials for regenerating dental tissues.
机译：通过去除感染的牙科组织如牙本质并用材料恢复牙齿来治疗牙科衰减。然而，绝大多数这些材料被设计为机械稳健和生物素，而尚未考虑生物材料的潜在再生性能。例如，在牙髓用药中，材料用于密封纸浆腔以避免牙齿的细菌定植并防止进一步感染。虽然这些处理在短期内有效，但是许多这些材料尚未设计成以生物相容性的方式与纸浆组织界面，并且通常是细胞毒性的。这可能导致不太有利的长期成果，例如通过根管治疗或齿的牙齿的去活化。如果遵循再生方法，可以改善临床结果，其中牙齿的生物学经常使用生物材料的载体来修复和再生。在这些中，无细胞或细胞归巢方法特别有趣，因为可以避免与细胞疗法相关的一些调节障碍，这可能有助于其临床翻译。在这篇综述中，我们突出了再生牙科的进展，并专注于利用细胞生物材料进行再生牙科组织的激动发展。

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