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首页> 外文期刊>Biomaterials Science >Dually regulating the proliferation and the immune microenvironment of melanoma via nanoparticle-delivered siRNA targeting onco-immunologic CD155
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Dually regulating the proliferation and the immune microenvironment of melanoma via nanoparticle-delivered siRNA targeting onco-immunologic CD155

机译：通过纳米颗粒递送的SiRNA靶向甲基免疫学CD155，用纳米粒子递送的siRNA进行异常调节黑素瘤的增殖和免疫微环境

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摘要

Studies have shown that the simultaneous regulation of tumor cell proliferation and the suppressive tumor immune microenvironment (TIME) could achieve better therapeutic effects. However, the targets of the proliferation and the TIME are different, which greatly limits the development of cancer therapy. A recent study found CD155, a highly expressed poliovirus receptor in melanoma cells and melanoma-infiltrating macrophages, functions as both an oncogene and immune checkpoint. Thus, it is supposed that targeting CD155 could bring dual therapeutic effects. Herein, we propose silencing the CD155 of melanoma cells and melanoma-infiltrating macrophages by a nanoparticle-delivered small interference RNA (siRNA) targeting CD155 (siCD155). We encapsulated siCD155 into cationic lipid-assisted nanoparticles (CLAN(siCD155)) and demonstrated that the intravenous injection of CLAN(siCD155) could efficiently deliver siCD155 into melanoma cells and melanoma-infiltrating macrophages. The downregulation of CD155 in melanoma cells directly inhibited their proliferation, and meanwhile, the downregulation of CD155 in melanoma-infiltrating macrophages increased the activation of NK cells and T cells. Owing to this dual effect, CLAN(siCD155) significantly inhibited the growth of B16-F10 melanoma. Our study suggests that nanoparticle-delivered siCD155 may be a simple but effective strategy for inhibiting tumor proliferation and reprogramming TIME.
机译：研究表明，同时调节肿瘤细胞增殖和抑制肿瘤免疫微环境（时间）可以达到更好的治疗效果。然而，增殖和时间的目标是不同的，这极大地限制了癌症治疗的发展。最近的一项研究发现了CD155，一种高表达的脊髓灰质炎病毒在黑素瘤细胞和黑色素瘤浸润巨噬细胞中，用作癌基因和免疫检查点。因此，假设靶向CD155可以带来双重治疗效果。在此，我们提出通过纳米颗粒递送的小干扰RNA（siRNA）沉默黑色素瘤细胞和黑色素瘤浸润巨噬细胞的CD155（SiCD155）。我们将SICD155封装成阳离子脂辅助纳米颗粒（氏族（SICD155）），并证明静脉注射氏族（SICD155）可以有效地将SICD155提供给黑色素瘤细胞和黑色素瘤浸润的巨噬细胞。 CD155在黑色素瘤细胞中的下调直接抑制它们的增殖，同时，CD155在黑素瘤浸润巨噬细胞的下调增加了NK细胞和T细胞的活化。由于这种双重效应，氏族（SICD155）显着抑制了B16-F10黑色素瘤的生长。我们的研究表明，纳米粒子交付的SICD155可能是抑制肿瘤增殖和重编程时间的简单但有效的策略。

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  • 来源
    《Biomaterials Science》 |2020年第23期|共12页
  • 作者

    Wang Yan; Luo Ying-Li; Chen Yi-Fang; Lu Zi-Dong; Wang Yue; Czarna Anna; Shen Song; Xu Cong-Fei; Wang Jun;

  • 作者单位

    South China Univ Technol Sch Med Inst Life Sci Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Med Inst Life Sci Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Med Inst Life Sci Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Med Inst Life Sci Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Biomed Sci &

    Engn Guangzhou Int Campus Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Med Inst Life Sci Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Biomed Sci &

    Engn Guangzhou Int Campus Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Biomed Sci &

    Engn Guangzhou Int Campus Guangzhou 510006 Peoples R China;

    South China Univ Technol Sch Biomed Sci &

    Engn Guangzhou Int Campus Guangzhou 510006 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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