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首页> 外文期刊>Biomaterials Science >Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement
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Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement

机译：缺氧响应性和uPerconversion纳米颗粒改性RBC微载体的制备用于氧输送和化疗增强

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Solid tumor cells in hypoxic regions resist chemotherapy treatment with conventional antitumor drugs (such as paclitaxel, PTX) because the inadequate O(2)attenuates the intracellular generation of reactive oxygen species (ROS) and upregulates multidrug resistance protein expression. Hyperbaric O(2)therapy concentrates on improving O(2)delivery to the hypoxic tumor area, thereby enhancing the sensitivity of cancer cells to chemotherapy drugs. However, the implementation of this therapy often elicits immune response or potentiates toxicity of the drugs toward normal cells. In this work, we successfully fabricated RBC-based micro-vehicles for precise hypoxia-activated O(2)delivery under the 980 nm laser irradiation. Interestingly, the subsequent chemotherapy of PTX for ovarian tumors was significantly enhanced owing to the alleviation of hypoxia tumor microenvironment. Meanwhile, the RBC-based micro-vehicles have low side tissue effects, superior biocompatibility, and ultra-low immune response. Overall, the RBC-based drug delivery system holds a fascinating perspective towards O(2)delivery for chemotherapy enhancement in other clinical solid malignancies.
机译：缺氧区域中的固体肿瘤细胞抵抗常规抗肿瘤药物（例如紫杉醇，PTX）的化疗治疗，因为O（2）不足衰减细胞内产生反应性氧物质（ROS），并越轮换多药耐药蛋白表达。高压O（2）治疗浓缩物，以改善o（2）递送给缺氧肿瘤区域，从而提高癌细胞对化疗药物的敏感性。然而，这种治疗的实施通常会引发免疫应答或增强药物对正常细胞的毒性。在这项工作中，我们在980nm激光照射下成功地制造了基于RBC的微型载体的缺氧激活的O（2）输送。有趣的是，由于减轻缺氧肿瘤微环境，随后的卵巢肿瘤PTX的化学疗法显着提高。同时，基于RBC的微型载体具有低侧面组织效应，优异的生物相容性和超低免疫应答。总的来说，基于RBC的药物递送系统对其他临床固体恶性肿瘤中的化疗增强进行了令人着迷的观点。

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