...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomaterials Science >Tannic acid-based nanogel as an efficient anti-inflammatory agent
【24h】

Tannic acid-based nanogel as an efficient anti-inflammatory agent

机译：鞣酸基纳凝胶作为一种有效的抗炎剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biologically produced reactive oxygen species (ROS) are important signaling molecules in the human body. Despite their importance under normal conditions, abnormal overproduction of ROS under unbalanced or irregular homeostasis can cause severe inflammatory diseases. Various antioxidants have been developed in the biomedical field to resolve high levels of ROS; however, high doses of natural antioxidants such as polyphenol can induce side effects on health. Further, synthetic antioxidants are still controversial in regards to their safety and their complicated synthesis. Inspired from our previous work, a nitric oxide-scavenging nanogel designed for treating rheumatoid arthritis, we report herein a biocompatible tannic acid (TA)-based nanogel as an effective ROS scavenger. A polymeric phenylboronic acid-tannic acid nanogel (PTNG) was prepared by simply mixing through to the formation of phenylboronic ester bonds between polymeric phenylboronate and TA. We focused on the reaction of phenylboronic ester with H2O2, which readily consumes H2O2 molecules, and applied it as an antioxidant. In addition, TA is a well-known antioxidant, specifically a free radical scavenger; thus, we expected combinatory ROS scavenging effects for PTNG. Various ROS scavenging assays revealed the significant antioxidant effects of PTNG. Under an induced inflammation model in vitro, our PTNG showed high biocompatibility as well as strong anti-inflammatory effects. Furthermore, in the zymosan-induced peritonitis mouse model, a representative acute inflammation model in vivo, PTNG reduced significant neutrophil recruitment and pro-inflammatory cytokines, indicating successful alleviation of inflammation. On the basis of these results, we suggest that PTNG has great potential as an antioxidant and should find application in the treatment of further ROS-overproducing inflammatory diseases.
机译：生物生产的活性氧（ROS）是人体中的重要信号传导分子。尽管在正常情况下具有重要性，但不平衡或不规则稳态下ROS异常过量生产可能导致严重的炎症疾病。在生物医学领域开发了各种抗氧化剂以解决高水平的ROS;然而，高剂量的天然抗氧化剂如多酚可以诱导对健康的副作用。此外，对其安全性及其复杂合成的合成抗氧化剂仍存在争议。灵感来自我们之前的工作，一氧化碳清除纳池设计用于治疗类风湿性关节炎，我们在本文中报告了一种生物相容的单宁酸（TA）基蛙作为有效的ROS清除剂。通过简单地将聚合物苯基酯与TA之间的苯基硼酸酯键的形成来制备聚合物苯基硼酸 - 单烷酸纳米凝胶（PTNG）。我们专注于苯基硼酸酯与H 2 O 2的反应，该H2O2容易消耗H 2 O 2分子，并作为抗氧化剂施加。此外，TA是众所周知的抗氧化剂，特别是自由基清除剂;因此，我们预计对PTNG的组合ROS清除作用。各种ROS清除测定显示PTNG的显着抗氧化作用。在体外诱导的炎症模型下，我们的PTNG显示出高的生物相容性以及强烈的抗炎作用。此外，在酵母诱导的腹膜炎小鼠模型中，体内急性炎症模型，PTNG减少了显着的中性粒细胞募集和促炎细胞因子，表明炎症的成功减轻了炎症。在这些结果的基础上，我们建议PTNG作为抗氧化剂具有很大的潜力，并且应该在治疗进一步的ROS过度炎症疾病方面进行应用。

著录项

  • 来源
    《Biomaterials Science》 |2020年第4期|共12页
  • 作者

    Yeo Jiwon; Lee Junseok; Yoon Seonyeong; Kim Won Jong;

  • 作者单位

    Pohang Univ Sci &

    Technol POSTECH Dept Chem Pohang 37673 South Korea;

    Pohang Univ Sci &

    Technol POSTECH Dept Chem Pohang 37673 South Korea;

    Pohang Univ Sci &

    Technol POSTECH Dept Chem Pohang 37673 South Korea;

    Pohang Univ Sci &

    Technol POSTECH Dept Chem Pohang 37673 South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号