Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties

Okesola Babatunde O.; Lau Hang K.; Derkus Burak; Boccorh Delali K.; Wu Yuanhao; Wark Alastair W.; Kiick Kristi L.; Mata Alvaro

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Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties

机译：具有受控纳米结构和改善的机械性能的ResiLiN样多肽和肽两亲物之间的共价加入水凝胶中的水凝胶

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Covalent co-assembly holds great promise for the fabrication of hydrogels with controllable nanostructure, versatile chemical composition, and enhanced mechanical properties given its relative simplicity, high efficiency, and bond stability. This report describes our approach to designing functional multicomponent hydrogels based on photo-induced chemical interactions between an acrylamide-functionalized resilin-like polypeptide (RLP) and a peptide amphiphile (PA). Circular dichroism (CD) spectroscopy, electron microscopy, and amplitude sweep rheology were used to demonstrate that the co-assembled hydrogel systems acquired distinct structural conformations, tunable nanostructures, and enhanced elasticity in a PA concentration-dependent manner. We envisage the use of these materials in numerous biomedical applications such as controlled drug release systems, microfluidic devices, and scaffolds for tissue engineering.

机译：共价共同组装对具有可控纳米结构，通用化学成分的水凝胶的制备具有很大的希望，并且鉴于其相对简单，高效率和粘合稳定性，具有增强的机械性能。本报告描述了我们基于丙烯酰胺官能化的丙烯醛样多肽（RLP）与肽两亲物（PA）之间的光诱导的化学相互作用来设计功能多组分水凝胶的方法。圆形二中间谱（CD）光谱，电子显微镜和幅度扫描流变学用于证明共组合的水凝胶系统以PA浓度依赖性方式获得了不同的结构构象，可调谐纳米结构和增强的弹性。我们设想在许多生物医学应用中使用这些材料，例如受控药物释放系统，微流体装置和用于组织工程的支架。

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《Biomaterials Science》 |2020年第3期|共12页
作者
Okesola Babatunde O.; Lau Hang K.; Derkus Burak; Boccorh Delali K.; Wu Yuanhao; Wark Alastair W.; Kiick Kristi L.; Mata Alvaro;
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作者单位

Queen Mary Univ London Inst Bioengn Mile End Rd London E1 4NS England;

Univ Delaware Dept Mat Sci &

Engn 201 DuPont Hall Newark DE 19716 USA;

Queen Mary Univ London Inst Bioengn Mile End Rd London E1 4NS England;

Univ Strathclyde Ctr Mol Nantnetrol Technol &

Innovat Ctr Dept Pure &

Appl Chem 99 George St Glasgow G1 1RD Lanark Scotland;

Queen Mary Univ London Inst Bioengn Mile End Rd London E1 4NS England;

Univ Strathclyde Ctr Mol Nantnetrol Technol &

Innovat Ctr Dept Pure &

Appl Chem 99 George St Glasgow G1 1RD Lanark Scotland;

Univ Delaware Dept Mat Sci &

Engn 201 DuPont Hall Newark DE 19716 USA;

Queen Mary Univ London Inst Bioengn Mile End Rd London E1 4NS England;

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正文语种 eng
中图分类分子生物学;
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专利

1. Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties [J] . Okesola Babatunde O., Lau Hang K., Derkus Burak, Biomaterials Science . 2020,第3期

机译：具有受控纳米结构和改善的机械性能的ResiLiN样多肽和肽两亲物之间的共价加入水凝胶中的水凝胶
2. Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization [J] . Chongyi Chen, Decheng Wu, Wenxin Fu Biomacromolecules . 2013,第8期

机译：由开环聚合制备的非离子烷基多肽两亲物组装的肽水凝胶
3. Thiol-ene Photocrosslinking of Cytocompatible Resilin-Like Polypeptide-PEG Hydrogels [J] . McGann Christopher L., Dumm Rebekah E., Jurusik Anna K., Macromolecular bioscience . 2016,第1期

机译：细胞相容性类似Resilin的多肽-PEG水凝胶的硫醇-烯光交联
4. Three-dimensional Culture of Mesenchymal Stem Cells Encapsulated in Resilin-like Polypeptide Hydrogels [C] . Atsushi Mahara, Linqing Li, Tetsuji Yamaoka Polymeric Materials: Science Engineering Symposia . 2010

机译：Resilin样多肽水凝胶中包封的间充质干细胞的三维培养物
5. Resilin-like polypeptide-poly(ethylene gylcol) hybrid hydrogels for mechanically-demanding tissue engineering applications. [D] . McGann, Christopher Leland. 2015

机译：用于机械需求的组织工程应用的类Resilin多肽（聚乙二醇）杂化水凝胶。
6. Controlling Mechanical Properties of Cell-Laden Hydrogels by Covalent Incorporation of Graphene Oxide [O] . Dr. Chaenyung Cha, Dr. Su Ryon Shin, Xiguang Gao, -1

机译：通过共价掺入氧化石墨烯控制含细胞水凝胶的机械性能
7. Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties [O] . Babatunde O. Okesola, Hang K. Lau, Burak Derkus, 2020

机译：具有受控纳米结构和改善的机械性能的ResiLiN样多肽和肽两亲物之间的共价加入水凝胶中的水凝胶

Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties

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