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Modulation of immune responses with nanoparticles and reduction of their immunotoxicity

机译:用纳米颗粒的免疫应答和减少免疫毒性的调节

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摘要

Particles with a size range of 1-100 nm used in various fields of life sciences are called nanoparticles (NPs). Currently, nanotechnology has a wide range of applications in biomedical research, industries and in almost all types of modern technology. The growing applications of nanotechnology in medicine urge scientists to analyze the impact of NPs on human body tissues and the immune system. Easy surface modifications of the NPs enable the modulation of the immune system either by evading the immune system to prevent allergic reactions or by enhancing the immunogenic response. In this review, we discussed the various possible theories and practical implications reported to date for the applications of nanotechnology in immunostimulation and immunosuppression for favorable immune response, such as vaccine delivery and cancer treatments. In the last part of this paper, we also discussed the biocompatibility and unfavorable immunotoxicity of NPs and methods for lowering their toxicity.
机译:在各种生命科领域中使用的尺寸范围为1-100nm的颗粒称为纳米颗粒(NPS)。 目前,纳米技术在生物医学研究,行业和几乎所有类型的现代技术中具有广泛的应用。 纳米技术在医学中的越来越多的应用敦促科学家分析NPS对人体组织和免疫系统的影响。 通过疏水免疫系统来防止过敏反应或通过提高免疫原性反应,易于表面修饰,可以通过疏入免疫系统来调节免疫系统。 在这篇综述中,我们讨论了迄今为止纳米技术在免疫刺激和免疫抑制中的应用迄今为止的各种可能的理论和实际影响,例如疫苗递送和癌症治疗。 在本文的最后一部分中,我们还讨论了NPS的生物相容性和不利的免疫毒性和降低毒性的方法。

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