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首页> 外文期刊>Biomaterials Science >Single-step formulation of levodopa-based nanotheranostics - strategy for ultra-sensitive high longitudinal relaxivity MRI guided switchable therapeutics
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Single-step formulation of levodopa-based nanotheranostics - strategy for ultra-sensitive high longitudinal relaxivity MRI guided switchable therapeutics

机译：基于Levodopa的纳米移植器的单步制剂 - 超敏感高纵向松弛率MRI引导可切换治疗策略

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Nanotheranostics (combined diagnosis and therapy) is emerging as an integral part of future therapeutic strategies. However, the development and fabrication of a nanotheranostic module involves multistep processes and always faces formulation challenges. The complexity involved in its multi-step formulations hinders its reproducible industrial production and clinical translation. Therefore, a facile synthesis of multifunctional nanotheranostics is critical to its translational success. In this report, we have developed a one-pot facile strategy to prepare a MRI-visible photothermal theranostic switchable module (T-SWITCH). These nanoparticles are synthesized through polymerization of levodopa together with the reduction of KMnO4 in the presence of silk sericin for the formation of manganese dioxide particles within the T-SWITCH. The synthesized T-SWITCH showed a uniform size distribution of around 95.77 nm and high longitudinal relaxivity coefficient (r(1)) of up to 61.94 mM(-1) s(-1). The reported r(1) of the T-SWITCH is exceedingly higher than that of any other previously reported manganese-based contrast agents with first-rate in vitro and in vivo contrast enhancement capability. The T-SWITCH can be activated to switch its therapeutic mode using near-infrared (NIR) light. It exhibited strong excitable absorption in the safer and biological NIR window between 650 and 900 nm. We have validated the significant anti-cancer therapeutic efficacy of T-SWITCH both in vitro and in vivo through switchable photothermal therapy.
机译：纳米移植（综合诊断和治疗）被涌现为未来治疗策略的组成部分。然而，纳米移位模块的开发和制造涉及多步骤过程，并始终面临配方挑战。其多阶段配方中涉及的复杂性阻碍了其可重复的工业生产和临床翻译。因此，对多功能纳米移位的容易合成对其翻译成功至关重要。在本报告中，我们开发了一种单罐的容易策略，用于制备MRI可见光的光热Theranostic可切换模块（T-Switch）。这些纳米颗粒通过Levodopa的聚合合成，并在丝霉素的存在下，在丝丝蛋白存在下进行KMnO 4，以形成T型开关内的二氧化锰颗粒。合成的T-Switch显示出约95.77nm和高纵向松弛系数（R（1））的均匀尺寸分布，高达61.94mm（-1）（-1）。 T-Switch的报告的R（1）非常高于任何其他先前报告的基于锰的造影剂，其具有第一速率和体内对比增强能力。可以激活T-Switch以使用近红外（NIR）光切换其治疗模式。它在650至900纳米之间表现出更安全和生物NIR窗口中的强烈兴奋吸收。通过可切换的光热疗法验证了T-Switch的显着抗癌治疗疗效。

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