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首页> 外文期刊>Biomaterials Science >'Swiss roll'-like bioactive hybrid scaffolds for promoting bone tissue ingrowth and tendon-bone healing after anterior cruciate ligament reconstruction
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'Swiss roll'-like bioactive hybrid scaffolds for promoting bone tissue ingrowth and tendon-bone healing after anterior cruciate ligament reconstruction

机译：“瑞士卷” - 麦克芹生物活性杂交支架，用于促进骨组织脾脏和肌腱骨愈合后，前十字韧带重建后

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摘要

The choice of grafts for anterior cruciate ligament (ACL) reconstruction is a critical issue in sports medicine. Previous studies have revealed that scaffolds prepared from a single material could not achieve complete integration between the graft and autogenous bone tunnel. To solve this problem, we hypothesize that combining degradable scaffolds with nondegradable scaffolds can produce a novel hybrid ligament with the advantages of both types of scaffolds. In this study, a bone morphogenetic protein 7 (BMP-7)-loaded polycaprolactone (PCL) nanofibrous membrane was first manufactured as the degradable part of the hybrid ligament by using layer-by-layer (LbL) self-assembly. Then, we fabricated a multifunctional novel hybrid ligament by rolling up this nanofibrous membrane and polyethylene terephthalate (PET) mesh fabric (nondegradable part) into a "swiss roll" structure. The in vitro experimental results showed that this hybrid ligament could significantly improve the biocompatibility of pure PET ligament and further promote cell mineralization. The in vivo experimental results showed that this unique structure significantly promoted the integration of hybrid ligaments and bone tunnels, thereby achieving real "ligamentization" after ACL reconstruction surgery. These results suggest that this novel hybrid biomimetic artificial ligament scaffold provides a new direction for graft selection for ACL reconstruction.
机译：对前十字韧带（ACL）重建的移植物的选择是运动医学中的一个关键问题。以前的研究表明，由单一材料制备的支架无法在移植物和自生骨隧道之间实现完全整合。为了解决这个问题，我们假设用非球状支架结合可降解的支架可以产生具有两种类型支架的优点的新型杂交韧带。在该研究中，首先通过使用逐层（LBL）自组装来制造作为杂化韧带的可降解部分的骨形态发生蛋白7（BMP-7） - 加载的聚己内酯（PCL）纳米纤维膜。然后，我们通过将该纳米纤维膜和聚对苯二甲酸乙二醇酯（PET）网织物（NondAllape部分）升至“瑞士卷”结构来制造多功能新的杂交韧带。体外实验结果表明，该杂交韧带可显着提高纯PET韧带的生物相容性，进一步促进细胞矿化。体内实验结果表明，这种独特的结构显着促进了杂交韧带和骨隧道的整合，从而在ACL重建手术后实现了真实的“韧化”。这些结果表明，这种新型杂化仿生人工韧带支架为ACL重建提供了接枝选择的新方向。

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  • 来源
    《Biomaterials Science》 |2020年第3期|共13页
  • 作者

    Zhang Peng; Han Fei; Chen Tianwu; Wu Ziying; Chen Shiyi;

  • 作者单位

    Fudan Univ Huashan Hosp Dept Sports Med Shanghai 200040 Peoples R China;

    Tongji Univ Shanghai East Hosp Inst Translat Med Inst Biomed Engn &

    Nanosci Sch Med Shanghai 200092 Peoples R China;

    Fudan Univ Huashan Hosp Dept Sports Med Shanghai 200040 Peoples R China;

    Fudan Univ Huashan Hosp Dept Sports Med Shanghai 200040 Peoples R China;

    Fudan Univ Huashan Hosp Dept Sports Med Shanghai 200040 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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