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首页> 外文期刊>Biomaterials Science >Shear-thinning hyaluronan-based fluid hydrogels to modulate viscoelastic properties of osteoarthritis synovial fluids
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Shear-thinning hyaluronan-based fluid hydrogels to modulate viscoelastic properties of osteoarthritis synovial fluids

机译：剪切稀疏透明质酸液水凝胶，调节骨关节炎滑液的粘弹性性能

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摘要

Hyaluronan (hyaluronic acid, HA) has been extensively explored as an attractive biomaterial for biomedical and pharmaceutical applications due to its unique physiological properties. In particular, HA is a major component of synovial fluid in normal knee joints and provides viscoelastic properties to synovial fluid. In osteoarthritic joints, synovial fluid loses its unique viscoelastic and lubrication properties. Intra-articular injection of HA in osteoarthritic knee joints is believed to restore viscoelasticity and lubrication abilities to synovial fluid. However, the main drawback of HA is its rapid degradation in synovial fluid. In order to overcome the problem of rapid clearance of HA, a HA-based hydrogel (vinyl sulfone-modified HA crosslinked by dithiol-terminated poly(ethylene glycol), HA-VS/SH-2-PEG) was synthesized in this study. Injectable fluid hydrogels (viscosupplements) possessing tunable viscoelasticity and controllable degradation rates were then prepared by adding HA-VS/SH-2-PEG microgels to HA solutions. The resultant viscosupplements exhibit enhanced viscoelastic properties, lubrication effects, efficient triamcinolone acetonide payload capacity, and high resistance to enzymatic degradation along with good biocompatibility and the capability to inhibit the progression of osteoarthritis in vivo. Overall, the results provide support for the use of injectable fluid hydrogels as a strategy for the treatment of osteoarthritis and potential for the clinical translation.
机译：由于其独特的生理特性，透明质酸（透明质酸，HA）被广泛探索为生物医学和药物应用的有吸引力的生物材料。特别地，HA是正常膝关节中的滑膜流体的主要成分，并为滑膜流体提供粘弹性。在骨关节炎关节中，滑膜失去其独特的粘弹性和润滑性能。据信在骨关节炎膝关节中的关节内注射HA恢复粘弹性和润滑能力对滑液。然而，HA的主要缺点是滑膜流体的快速降解。为了克服HA的快速清除问题，在本研究中合成了一种基于HA的水凝胶（通过二硫醇封端的聚（乙二醇），HA-VS / SH-2-PEG交联的乙烯基砜改性的HA。然后通过将HA-VS / SH-2-PEG微凝胶添加到HA溶液，制备具有可调谐粘弹性和可控降解速率的可注射的流体水凝胶（粘度化）。所得粘度化合物表现出增强的粘弹性，润滑效果，高效的曲胺酮醋酸乙酰丙烯酯有效载荷能力，以及高抗性酶促降解以及良好的生物相容性和抑制体内骨关节炎进展的能力。总体而言，结果提供了对使用可注射液水凝胶作为治疗骨关节炎和临床翻译潜力的策略的支持。

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  • 来源
    《Biomaterials Science》 |2019年第8期|共15页
  • 作者

    Cai Zhixiang; Zhang Hongbin; Wei Yue; Wu Min; Fu Ailing;

  • 作者单位

    Shanghai Jiao Tong Univ Adv Rheol Inst Dept Polymer Sci &

    Engn Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Adv Rheol Inst Dept Polymer Sci &

    Engn Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Adv Rheol Inst Dept Polymer Sci &

    Engn Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jiao Tong Univ Adv Rheol Inst Dept Polymer Sci &

    Engn Sch Chem &

    Chem Engn Shanghai 200240 Peoples R China;

    Shanghai Jingfeng Pharmaceut Co Ltd Shanghai 200120 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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