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首页> 外文期刊>Biomaterials Science >The antibacterial and antibiofilm activities of mesoporous hollow Fe(3)O(4)nanoparticles in an alternating magnetic field
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The antibacterial and antibiofilm activities of mesoporous hollow Fe(3)O(4)nanoparticles in an alternating magnetic field

机译：开孔中空Fe（3）o（4）纳米粒子在交流场中的抗菌和抗菌和抗菌活性

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摘要

Unrestricted usage of antibiotics has accelerated the emergence of new strains of microorganisms with antimicrobial resistance (AMR) and the development of therapeutic technologies that do not rely only on antibiotics. Herein, mesoporous hollow Fe(3)O(4)nanoparticles (MHFPs) were synthesized by a one-pot hydrothermal method, and the feasibility and possible mechanism of using alternating magnetic field (AMF) with MHFPs to killEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus) were explored. The presence of the AMF (2.5 kW, 210 kHz) combined with the MHFPs resulted in a dramatic decrease in colony forming units (CFU) forE. coliandS. aureusin 25 min compared with the pure MHFPs at concentrations of 500, 800 and 1000 mu g mL(-1). Macroscopic hyperthermia was proved not to be the sole reason for the phenomenon. Visible membrane damage was demonstrated by live/dead staining, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) assays. Besides, the permeability and integrity changes of the cell membrane were then quantitatively confirmed by measuring the relative electrical conductivity. In addition, bacterial biofilms were significantly dispersed in the presence of MHFPs and AMF. These results suggested that under the mediation of AMF, MHFPs can potentially serve as an efficient nonantibiotic therapeutic platform to disperse bacterial biofilms and inactivate bacteria by damaging the cell membrane of the bacteria.
机译：不受限制的抗生素的使用加速了抗微生物抗性（AMR）新的微生物菌株的出现，以及不仅依赖于抗生素的治疗技术的发展。在此，通过单壶水热法合成介孔中空Fe（3）α（4）α（4）α纳米颗粒（MHFP），以及使用MHFP与Killescherichia Coli（例如Coli）的交替磁场（AMF）的可行性和可能机制探索了Andstaphylococcus aureus（金黄色葡萄球菌）。联合MHFP的AMF（2.5kW，210 kHz）的存在导致菌落形成单位（CFU）的显着降低。哥伦比亚。 Aureusin 25分钟与纯度MHFP相比，浓度为500,800和1000μgmm（-1）。证明了宏观热疗不作为现象的唯一原因。通过活/死染色，扫描电子显微镜（SEM）和透射电子显微镜（TEM）测定证明了可见膜损伤。此外，然后通过测量相对导电性来定量地确认细胞膜的渗透性和完整性变化。此外，细菌生物膜在MHFPS和AMF存在下显着分散。这些结果表明，在AMF的中介，MHFP可以作为有效的非抗生素治疗平台来分散细菌生物膜并通过损坏细菌的细胞膜来灭活细菌。

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