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首页> 外文期刊>Biomaterials Science >Core-shell particles for drug-delivery, bioimaging, sensing, and tissue engineering
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Core-shell particles for drug-delivery, bioimaging, sensing, and tissue engineering

机译：用于药物输送，生物分析，传感和组织工程的核 - 壳颗粒

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Nanoparticles have been widely used for many applications such as catalysis, biomedicine, or self-healing. Core-shell nanoparticles are very promising for biomedical applications due to several features such as possibility of sequence-controlled release of drugs and protection of sensitive payloads from surrounding environment. Core-shell structures incorporating payloads such as drugs, peptides, or hormones have been investigated in pre-clinical studies. The present review describes state of the art techniques for designing core-shell particles for biomedical applications. We also present recent advances in the field of drug, protein/peptide, and gene delivery using different types of core-shell nanoparticles. The function of core-shell particles as contrast agents and labels for bioimaging in magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography imaging (CT), ultrasound, and optical imaging is highlighted as well as their applications as biosensors.
机译：纳米粒子已广泛用于许多应用，例如催化，生物医学或自我愈合。由于若干特征，核 - 壳纳米粒子对生物医学应用非常有前途，例如序列控制的药物序列释放的可能性和保护敏感有效载荷的可能性。在临床前研究中已经研究了包含有效载荷的核心壳结构，例如药物，肽或激素。本综述描述了用于设计生物医学应用的核心壳颗粒的现有技术的状态。我们还使用不同类型的核 - 壳纳米颗粒在药物，蛋白质/肽和基因递送领域的最近的进展。核心 - 壳颗粒作为磁共振成像（MRI），正电子发射断层扫描（PET），计算机断层摄影成像（CT），超声波和光学成像的造影剂和用于生物成像的标签以及它们作为生物传感器的应用。

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