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首页> 外文期刊>Biomechanics and modeling in mechanobiology >A growth-based model for the prediction of fiber angle distribution in the intervertebral disc annulus fibrosus
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A growth-based model for the prediction of fiber angle distribution in the intervertebral disc annulus fibrosus

机译：基于生长的模型，用于预测椎间盘环纤维纤维纤维角分布

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摘要

There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in implementing these models is that the outer annulus fibrosus of the disc is composed of concentric sheets of aligned collagen fibers, the helical angles of which vary spatially. In finite element models, fiber angle is typically assumed to be constant, based on average experimental measurements from a small number of locations. The present study hypothesized that the full spatial distribution of fiber angles in the annulus fibrosus may be predicted for any disc geometry by assuming growth from a thin cylinder with constant fiber angle. This hypothesis was tested by developing an analytical model of disc growth and calibrating it with fiber angle measurements of adult bovine caudal discs. The calibrated model was then run on a representative human lumbar disc geometry. The model was able to accurately predict fiber angle distributions in both the experimental bovine caudal disc measurements and literature-reported human lumbar disc measurements. Despite its theoretical basis in development, the model requires only mature state geometry, making it practical for implementation in patient-specific finite element analyses, in which disc geometry is obtained from clinical imaging.
机译：对人类腰椎的患者特异性有限元模型的发展越来越感兴趣，以评估伤害风险和治疗策略的发展。实施这些模型的当前挑战是盘的外环纤维纤维由对齐胶原纤维的同心板组成，其螺旋角在空间上变化。在有限元模型中，通常假设光纤角度是恒定的，基于来自少量位置的平均实验测量。本研究假设通过假设具有恒定纤维角的薄圆筒的生长，可以预测环形纤维树中的纤维角度的全部空间分布。通过开发椎间盘生长的分析模型和校准成人牛尾盘的纤维角测量来测试该假设。然后在代表性的人腰椎间盘几何形状上运行校准的模型。该模型能够在实验牛尾盘测量和文献报告的人腰盘测量中准确地预测纤维角分布。尽管其在发展中具有理论基础，但该模型只需要成熟的状态几何形状，这对于患者特定的有限元分析中的实施方式进行了实用的，其中椎间盘几何形状是从临床影像中获得的。

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