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首页> 外文期刊>Biomechanics and modeling in mechanobiology >Comparative study of variations in mechanical stress and strain of human blood vessels: mechanical reference for vascular cell mechano-biology
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Comparative study of variations in mechanical stress and strain of human blood vessels: mechanical reference for vascular cell mechano-biology

机译：人体血管机械应力变化的比较研究：血管细胞机械 - 生物学的机械参考

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摘要

The diseases of human blood vessels are closely associated with local mechanical variations. A better understanding of the quantitative correlation in mechanical environment between the current mechano-biological studies and vascular physiological or pathological conditions in vivo is crucial for evaluating numerous existing results and exploring new factors for disease discovery. In this study, six representative human blood vessels with known experimental measurements were selected, and their stress and strain variations in vessel walls under different blood pressures were analyzed based on nonlinear elastic theory. The results suggest that conventional mechano-biological experiments seeking the different biological expressions of cells at high/low mechanical loadings are ambiguous as references for studying vascular diseases, because distinct "site-specific" characteristics appear in different vessels. The present results demonstrate that the inner surface of the vessel wall does not always suffer the most severe stretch under high blood pressures comparing to the outer surface. Higher tension on the outer surface of aortas supports the hypothesis of the outside-in inflammation dominated by aortic adventitial fibroblasts. These results indicate that cellular studies at different mechanical niches should be "disease-specific" as well. The present results demonstrate considerable stress gradients across the wall thickness, which indicate micro-scale mechanical variations existing around the vascular cells, and imply that the physiological or pathological changes are not static processes confined within isolated regions, but are coupled with dynamic cell behaviors such as migration. The results suggest that the stress gradients, as well as the mechanical stresses and strains, are key factors constituting the mechanical niches, which may shed new light on "factor-specific" experiments of vascular cell mechano-biology.
机译：人体血管的疾病与局部机械变化密切相关。更好地理解当前的机械生物学研究与体内血管生理或病理条件之间的机械环境之间的定量相关性对于评估许多现有结果并探索疾病发现的新因素至关重要。在该研究中，选择具有已知实验测量的六种代表性的人血管，基于非线性弹性理论分析了不同血压下不同血压下的容器壁的应力和应变变化。结果表明，寻求高/低机械负荷在高/低机械载荷的细胞不同生物学表达的常规机械生物实验是含糊不清的研究血管疾病的参考，因为不同的“特异性特异性”特征出现在不同的血管中。本结果表明，血管壁的内表面在与外表面相比的高血压下并不总是遭受最严重的伸展。主动脉外表面上的较高张力支持由主动脉患者成纤维细胞主导的外部炎症的假设。这些结果表明，不同机械效力的细胞研究也应该是“疾病特异性”。目前的结果表明墙壁厚度相当大的应力梯度，这表明存在周围的血管细胞周围的微观机械变化，暗示生理或病理变化不是局限于隔离区域内的静态过程，而是与动态细胞行为联系起来作为迁移。结果表明，应力梯度以及机械应力和菌株是构成机械效力的关键因素，这可能在血管细胞机械 - 生物学的“因子特异性”实验上阐述了新的光。

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