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首页> 外文期刊>Biochemistry and Cell Biology >Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats
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Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats

机译：乳铁蛋白与胆汁酸相互作用，并增加大鼠粪便胆固醇排泄

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摘要

I 8.2–8.9) in mammalian milk. We previously reported that enteric-LF prevented hypercholesterolemia and atherosclerosis in a diet-induced atherosclerosis model using Microminipig, although the underlying mechanisms remain unclear. Because LF is assumed to electrostatically interact with bile acids to inhibit intestinal cholesterol absorption, LF could promote cholesterol excretion. In this study, we assessed the interaction between LF and taurocholate in vitro, and the effect of LF on cholesterol excretion in rats. The binding rate of taurocholate to LF was significantly higher than that to transferrin (p I 5.2–6.3). When rats were administered a high-cholesterol diet (HCD) containing 5% LF, LF was detected using ELISA in the upper small intestine from 7.5 to 60 min after the administration. Rats were fed one of the following diets: control, HCD, or HCD + 5% LF for 21 days. Fecal neutral steroids and hepatic cholesterol levels in the HCD group were significantly higher than those in the control group. The addition of LF to a HCD significantly increased fecal neutral steroids levels (22% increase, p p R = ?0.63, p
机译：我8.2-8.9）在哺乳动物牛奶中。据报道，肠溶液预防饮食诱导的动脉粥样硬化模型中的高胆固醇血症和动脉粥样硬化，尽管下面的机制仍然不清楚。因为假设LF与胆汁酸静电相互作用以抑制肠道胆固醇的吸收，因此LF可以促进胆固醇排泄。在这项研究中，我们评估了LF和牛磺酸盐之间的相互作用，以及LF对大鼠胆固醇排泄的影响。牛磺酸杆菌对LF的结合率显着高于转铁蛋白（P i 5.2-6.3）。当施用大鼠含有5％LF的高胆固醇饮食（HCD）时，在给药后的7.5至60分钟的上小肠中使用ELISA检测LF。将大鼠送入以下饮食之一：对照，HCD或HCD + 5％LF 21天。 HCD组中的粪便中性类固醇和肝胆固醇水平明显高于对照组中的类固醇。添加LF至HCD显着增加粪便中性类固醇水平（增加22％，P P r = 0.63，P

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  • 来源
    《Biochemistry and Cell Biology》 |2017年第1期|共6页
  • 作者

    Kanae Nakamura; Satoru Morishita; Tomoji Ono; Michiaki Murakoshi; Keikichi Sugiyama; Hisanori Kato; Ikuo Ikeda; Hoyoku Nishino;

  • 作者单位

    Research and Development Headquarters Lion Corporation 100 Tajima Odawara Kanagawa 256-0811;

    Research and Development Headquarters Lion Corporation 100 Tajima Odawara Kanagawa 256-0811;

    Research and Development Headquarters Lion Corporation 100 Tajima Odawara Kanagawa 256-0811;

    Research and Development Headquarters Lion Corporation 100 Tajima Odawara Kanagawa 256-0811;

    Research and Development Headquarters Lion Corporation 100 Tajima Odawara Kanagawa 256-0811;

    “Food for Life” Organization for Interdisciplinary Research Projects The University of Tokyo 1-1;

    Laboratory of Food and Biomolecular Science Department of Food Function and Health Graduate;

    Kyoto Prefectural University of Medicine Kawaramachi-Hirokoji Kamigyou-ku Kyoto 602-0841 Japan.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    lactoferrin; cholesterol; bile acid; rats; hypercholesterolemia;

    机译：乳蛋白;胆固醇;胆汁酸;大鼠;高胆固醇血症;

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