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首页> 外文期刊>Biochemistry and Cell Biology >Effects of lactoferrin in 6 patients with refractory bacterial vaginosis
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Effects of lactoferrin in 6 patients with refractory bacterial vaginosis

机译：乳铁蛋白在6例难治性细菌阴道病患者中的影响

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We previously reported that lactoferrin (LF) could be effective for preventing preterm delivery and intrauterine infections, based on data derived from mice and rabbits. Here we describe 6 women with a history of multiple pregnancy losses or preterm delivery and refractory bacterial vaginosis, who received prebiotic LF therapy and delivered an infant normally. Five of the women were pregnant and one was not at the time of this study. The Ethics Committee at Showa University Hospital and Showa University Koto Toyosu Hospital approved the therapeutic protocol. Vaginal suppositories and oral prebiotic LF were administered to patients who were refractory to conventional treatment for vaginosis and had a history of late miscarriages and very early preterm delivery due to refractory vaginitis and chorioamnionitis. LF significantly improved the vaginal bacterial flora. Lactobacillus , which was detectable in the vaginas of all patients after one month of LF therapy, gradually became dominant. The findings from these 6 patients suggest that administering LF to humans could help prevent refractory vaginitis, cervical inflammation, and preterm delivery.
机译：我们之前报道，基于源自小鼠和兔的数据，乳铁蛋白（LF）可有效地预防早产输送和宫内感染。在这里，我们描述了6名患有多种妊娠损失或早产和难治性细菌阴道病的妇女，他们接受了益生元的LF疗法并正常递送婴儿。五名女性怀孕，一个不是在这项研究的时候。昭和大学医院伦理委员会和昭和丰富医院批准了治疗议定书。阴道栓剂和口服益生元LF给予常规治疗阴道病的难治患者，并且由于难治性阴化性阴茎炎和绒毛膜炎，患有晚期流产和早期早产的历史。 LF显着改善了阴道细菌菌群。乳酸杆菌，其在一个月的LF疗法后，在所有患者的vaginas中可检测到，逐渐成为主导。这6例患者的发现表明，将LF给人类施用有助于防止难治性阴道炎，宫颈炎炎症和早产。

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