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Metabolomics and fetal alcohol spectrum disorder

机译:代谢物和胎儿酒精谱系障碍

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Fetal alcohol spectrum disorder (FASD) is a major public health issue that encompass an array of physical, neurological, and behavioral effects due to alcohol consumption during pregnancy. The classical biomarkers of FASD that are currently used lack sensitivity and specificity, and as such there is an opportunity through the use of novel metabolomics analysis to identify new biomarkers to identify those at risk for FASD, which could more effectively aid in early intervention. The focus of this minireview is to identify current work that is being done in the field of metabolomics in FASD in utero, and to highlight promising metabolites that could act as biomarkers in the future. We will conclude with suggestions for further research, as there is a large gap of knowledge in this particular area of metabolomics.
机译:胎儿酒精谱系障碍(FASD)是一种主要的公共卫生问题,包括由于妊娠期间的饮酒而导致的身体,神经系统和行为效应。 目前使用的FASD的经典生物标志物缺乏敏感性和特异性,因此通过使用新的代谢组科分析有机会,以确定新的生物标志物,以确定对FASD风险的影响,这可以更有效地援助早期干预。 这个Minieview的重点是识别在子宫的Fasd中代谢组科领域正在进行的当前工作,并突出有希望的代谢物,可以在未来担任生物标志物。 我们将结束提出进一步研究的建议,因为在这种特定的代谢组科领域存在很大的知识。

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