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Thiamin deficiency on fetal brain development with and without prenatal alcohol exposure

机译：硫胺缺乏胎儿脑发育的疾病和没有产前酒精暴露

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Adequate thiamin levels are crucial for optimal health through maintenance of homeostasis and viability of metabolic enzymes, which require thiamine as a co-factor. Thiamin deficiency occurs during pregnancy when the dietary intake is inadequate or excessive alcohol is consumed. Thiamin deficiency leads to brain dysfunction because thiamin is involved in the synthesis of myelin and neurotransmitters (e.g., acetylcholine, γ-aminobutyric acid, glutamate), and its deficiency increases oxidative stress by decreasing the production of reducing agents. Thiamin deficiency also leads to neural membrane dysfunction, because thiamin is a structural component of mitochondrial and synaptosomal membranes. Similarly, in-utero exposure to alcohol leads to fetal brain dysfunction, resulting in negative effects such as fetal alcohol spectrum disorder (FASD). Thiamin deficiency and prenatal exposure to alcohol could act synergistically to produce negative effects on fetal development; however, this area of research is currently under-studied. This minireview summarizes the evidence for the potential role of thiamin deficiency in fetal brain development, with or without prenatal exposure to alcohol. Such evidence may influence the development of new nutritional strategies for preventing or mitigating the symptoms of FASD.
机译：通过维持性稳态和代谢酶的可行性需要硫胺素作为共同因素，适用于最佳健康至关重要。当膳食摄入不充分或消耗过量的酒精时，妊娠期缺乏症发生。硫胺素缺乏导致大脑功能障碍，因为硫胺素参与合成髓鞘和神经递质（例如，乙酰胆碱，γ-氨基丁酸，谷氨酸），其缺陷通过降低还原剂的产生来增加氧化应激。硫胺缺乏症也导致神经膜功能障碍，因为硫胺是线粒体和突触骨膜膜的结构组件。类似地，Utero暴露于酒精导致胎儿脑功能障碍，导致胎儿醇谱紊乱（FASD）等负面影响。硫胺素缺乏和产前暴露于酒精可以协同作用，对胎儿发育产生负面影响;然而，目前正在研究这个研究领域。这个米尼德观察总结了硫胺素缺乏在胎儿脑发育中的潜在作用的证据，有或没有产前暴露于酒精。这些证据可能会影响预防或减轻FASD症状的新营养策略的发展。

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