Renal collecting duct physiology and pathophysiology 1

Rawad Lashhab; A.K.M. Shahid Ullah; Emmanuelle Cordat

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Renal collecting duct physiology and pathophysiology 1

机译：肾脏收集管道生理学和病理生理学1

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In the kidney, the collecting duct (CD) is composed of at least four cell types: principal, type-A intercalated cells (IC), type-B IC, and non-A and non-B IC. Although this heterogeneous composition has been recognized since the end of the nineteenth century, the physiological role of the various cell types in the CD continues to be deciphered as of today. Principal and ICs are essential in ion–water balance and acid–base homeostasis, respectively. However, recent research has revealed a striking interplay and overlap between the specific functions of these cell types. This review summarizes the recent findings on CD cells and their role in multiple pathophysiologies.

机译：在肾脏中，收集管道（CD）由至少四种细胞类型组成：主体，型 - 插层（IC），型IC和非A和非B IC。尽管自十九世纪末以来已经认识到这种异质组合物，但CD中各种细胞类型的生理作用继续被截至今天。本金和ICS分别是离子水平衡和酸碱稳态。然而，最近的研究揭示了这些细胞类型的特定功能之间的醒目相互作用和重叠。本综述总结了最近CD细胞的发现及其在多种病理物理学中的作用。

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来源
《Biochemistry and Cell Biology》 |2019年第3期|共9页
作者
Rawad Lashhab; A.K.M. Shahid Ullah; Emmanuelle Cordat;
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作者单位

Department of Physiology and Membrane Protein and Disease Research Group University of Alberta;

Department of Physiology and Membrane Protein and Disease Research Group University of Alberta;

Department of Physiology and Membrane Protein and Disease Research Group University of Alberta;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
kidney; collecting duct; intercalated cells; principal cells; acid–base balance; pH homeostasis;

机译：肾脏;收集管道;插入细胞;主细胞;酸碱平衡;pH稳态;

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1. Renal collecting duct physiology and pathophysiology 1 [J] . Rawad Lashhab, A.K.M. Shahid Ullah, Emmanuelle Cordat Biochemistry and Cell Biology . 2019,第3期

机译：肾脏收集管道生理学和病理生理学1
2. Data integration in physiology using Bayes' rule and minimum Bayes' factors: deubiquitylating enzymes in the renal collecting duct [J] . Xue Zhe, Chen Jia-Xu, Zhao Yue, Physiological genomics . 2017,第3期

机译：使用贝叶斯规则和最小贝叶斯因子的生理数据集成：肾脏收集管道中的脱脂酶
3. Data integration in physiology using Bayes' rule and minimum Bayes' factors: deubiquitylating enzymes in the renal collecting duct [J] . Xue Zhe, Chen Jia-Xu, Zhao Yue, Physiological genomics . 2017,第3期

机译：使用贝叶斯规则和最小贝叶斯因子的生理数据集成：肾脏收集管道中的脱脂酶
4. H, Water and Urea Transport in the Inner Medullary Collecting Duct and Their Role in the Prevention and Pathogenesis of Renal Stone Disease [C] . Susan M. Wall, Janet D. Klein International Urolithiasis Research Symposium . 2008

机译：h，水和尿素运输在内髓内收集管道及其在肾石疾病预防和发病机制中的作用
5. Troglitazone induces extracellular matrix & cytoskeleton remodeling in the IMCD-K2 & M1 renal collecting duct cell lines. [D] . Corinaldi, Jaime. 2009

机译：曲格列酮诱导IMCD-K2和M1肾收集导管细胞系中的细胞外基质和细胞骨架重塑。
6. Proteomic and Metabolomic Approaches to Cell Physiology and Pathophysiology: Quantitative phosphoproteomics in nuclei of vasopressin-sensitive renal collecting duct cells [O] . Steven J. Bolger, Patricia A. Gonzales Hurtado, Jason D. Hoffert, -1

机译：蛋白质组学和代谢组学方法研究细胞生理学和病理生理学：血管加压素敏感的肾脏收集导管细胞核中的定量磷酸化蛋白质组学
7. Vinculin: Its Possible Use as a Marker of Normal Collecting Ducts and Renal Neoplasms with Collecting Duct System Phenotype [O] . Naoto Kuroda, Keishi Naruse, Eriko Miyazaki, 2000

机译：Vinculin：它可能用作具有收集管道系统表型的正常收集管道和肾肿瘤的标志物

Renal collecting duct physiology and pathophysiology 1

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