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首页> 外文期刊>Cytokine >Association between interleukin 10 gene -1082 A/G polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 4250 subjects
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Association between interleukin 10 gene -1082 A/G polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 4250 subjects

机译：白细胞介素10基因-1082 A / G多态性与2型糖尿病风险的关联：对4250名受试者的荟萃分析

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摘要

Increasing evidence suggests that interleukin 10 (IL 10) gene -1082 A/G (rsl800896) polymorphism may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the results are inconsistent. The aim of this study is to analyze the association between this variant and the T2DM risk by meta-analysis. PubMed, Embase, Web of Science, and Google Scholar were searched from January 1, 1989 to February 17, 2012, as well as hand searching of the references of identified articles were performed. All the statistical tests were performed using Stata 11.0. Seven case-control studies were identified, covering a total of 1879 T2DM cases and 2371 controls. The results showed evidence of significant association between IL 10 gene -1082 A/G polymorphism and T2DM risk (for G/G+G/A vs. A/A: OR=1.21, 95% CI=1.05-1.40, p=0.010, p=0.040 after Bonferroni testing). In the subgroup analysis by ethnicity, no significant association was found between IL 10 gene -1082 A/G polymorphism and T2DM risk in Europeans. In summary, results from this meta-analysis provide evidence that IL 10 gene -1082 G allele is associated with increased risk of T2DM.
机译：越来越多的证据表明，白介素10（IL 10）基因-1082 A / G（rs180896）多态性可能与2型糖尿病（T2DM）的风险增加有关。但是，结果不一致。这项研究的目的是通过荟萃分析来分析此变异与T2DM风险之间的关联。从1989年1月1日至2012年2月17日对PubMed，Embase，Web of Science和Google Scholar进行了搜索，并对发现的文章的参考文献进行了手工搜索。所有统计检验均使用Stata 11.0进行。确定了七项病例对照研究，涵盖总共1879例T2DM病例和2371例对照。结果表明有证据表明IL 10基因-1082 A / G多态性与T2DM风险显着相关（G / G + G / A vs.A / A：OR = 1.21，95％CI = 1.05-1.40，p = 0.010 ，在Bonferroni测试后，p = 0.040）。在按种族进行的亚组分析中，在欧洲人中没有发现IL 10基因-1082 A / G多态性与T2DM风险之间有显着关联。总之，这项荟萃分析的结果提供了证据，证明IL 10基因-1082 G等位基因与T2DM的风险增加有关。

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