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Conducting Biobehavioral Research in Patients With Advanced Cancer: Recruitment Challenges and Solutions

机译：患有先进癌症患者的生物侵蚀研究：招聘挑战和解决方案

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摘要

Despite significant advances in cancer treatment and symptom management interventions over the last decade, patients continue to struggle with cancer-related symptoms. Adequate baseline and longitudinal data are crucial for designing interventions to improve patient quality of life and reduce symptom burden; however, recruitment of patients with advanced cancer in longitudinal research is difficult. Our purpose is to describe challenges and solutions to recruitment of patients with advanced cancer in two biobehavioral research studies examining cancer-related symptoms. Study 1: Symptom data and peripheral blood for markers of inflammation were collected from newly diagnosed patients receiving chemotherapy on the first day of therapy and every 3–4 weeks for up to 6 months. Study 2: Symptom data, blood, and skin biopsies were collected from cancer patients taking epidermal growth factor receptor inhibitors at specific time points over 4 months. Screening and recruitment results for both studies are summarized. Timing informed consent with baseline data collection prior to treatment initiation was a significant recruitment challenge for both the studies. Possible solutions include tailoring recruitment to fit clinic needs, increasing research staff availability during clinic hours, and adding recruitment sites. Identifying solutions to these challenges will permit the conduct of studies that may lead to identification of factors contributing to variability in symptoms and development of tailored patient interventions for patients with advanced cancer.
机译：尽管过去十年癌症治疗和症状管理干预措施显着进展，但患者继续与癌症相关的症状斗争。适当的基线和纵向数据对于设计干预措施至关重要，以提高患者生活质量，减少症状负担;然而，在纵向研究中招募患有晚期癌症的患者是困难的。我们的目的是描述在两种生物教生物研究研究中招募晚期癌症患者的挑战和解决方案，检查癌症相关症状。研究1：在治疗的第一天接受化疗的新诊断患者中收集症状数据和外周血，每3-4周，每3-4周收集炎症的炎症标记。研究2：从癌症患者收集症状数据，血液和皮肤活组织检查，在4个月内特定时间点服用表皮生长因子受体抑制剂。综述了两项研究的筛选和招聘结果。在治疗开始前与基线数据收集的时序知情同意是对研究的重要招聘挑战。可能的解决方案包括裁剪招聘，以适应诊所需求，临床时间内的研究人员可用性以及添加招聘网站。确定这些挑战的解决方案将允许进行的研究，这些研究可能导致鉴定有助于症状的变异性的因素以及针对晚期癌症的患者的患者的定制患者干预措施。

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