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首页> 外文期刊>Cytokine >Serum cytokine profiles of Khorasan veterans 23 years after sulfur mustard exposure
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Serum cytokine profiles of Khorasan veterans 23 years after sulfur mustard exposure

机译：暴露于硫芥末后23年的霍拉桑退伍军人的血清细胞因子谱

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Sulfur mustard (SM) is an incapacitating chemical warfare agent that was used against Iranian soldiers during the period from 1983 to 1988. We have investigated serum cytokines profiles of Khorasan veterans who were exposed to SM >years earlier. Forty-four male Iranian veterans who had >40% disabilities due to delayed complications of SM poisoning and had disabilities were investigated. A total of 30 healthy male volunteers (relatives of the veterans) were selected as the control group. Cytokine levels were measured in the serum of case and control subjects using commercial ELISA kits. Hematologic parameters (white/red blood cell counts, hemoglobin levels, immune cell differentials) were also performed on blood samples from the study subjects. The results indicated that serum levels of ICAM-1 were significantly higher in the samples from SM-exposed veterans (772.8 [±15.1] ng/ml [.p=.0.014] vs. control values of 710.2 [±20.0] ng/ml). On the other hand, serum IL-1β, IL-8 levels and TNFα, were significantly lower for the veterans than the controls (IL-1β: 3.8 [±0.1] vs. 4.3 [±0.2] pg/ml, p=. 0.037; IL-8: 21.0 [±6.1] vs. 84.6 [±20.3] pg/ml, p=. 0.002; TNFα: 4.5 [±0.1] vs. 5.5 [± 0.1] pg/ml, p=. 0.027). Levels of other assayed cytokines, e.g., IL-2, -4, -5, -6, -10, and -12, IFNγ, TNFβ, and sVCAM-1 were not significantly different between the study populations. None of the assayed hematologic parameters appeared to differ as well. It seems possible that dysfunctions could have been induced in the innate immune functions of the SM-exposed veterans as a result of these changes in cytokine expression and that these, in turn, may have contributed to the increased incidence of a myriad of diseases that have been documented in these veterans, including cancers. Future studies must focus on examining the significance of these changes in circulating cytokines and their potential contribution to the development of different diseases in veterans exposed to SM.
机译：硫芥子油（SM）是一种无能的化学战剂，在1983年至1988年期间用于对付伊朗士兵。我们调查了几年前接触过SM的霍拉桑退伍军人的血清细胞因子谱。调查了四十四名伊朗男性退伍军人，他们由于SM中毒的延迟并发症而导致残疾率> 40％，并且有残疾。总共选择了30名健康的男性志愿者（退伍军人的亲属）作为对照组。使用市售ELISA试剂盒测量病例和对照组受试者血清中的细胞因子水平。还对研究对象的血液样本进行了血液学参数（白细胞/红细胞计数，血红蛋白水平，免疫细胞分化）。结果表明，暴露于SM的退伍军人的样品中ICAM-1的血清水平显着更高（772.8 [±15.1] ng / ml [.p = .0.014]，而对照值为710.2 [±20.0] ng / ml ）。另一方面，退伍军人的血清IL-1β，IL-8水平和TNFα显着低于对照组（IL-1β：3.8 [±0.1] pg / ml [4.3 [±0.2] pg / ml，p =。 0.037; IL-8：21.0 [±6.1] vs. 84.6 [±20.3] pg / ml，p = 0.002;TNFα：4.5 [±0.1] vs. 5.5 [±0.1] pg / ml，p = 0.027） 。在研究人群之间，其他测定的细胞因子（例如IL-2，-4，-5，-6，-10和-12，IFNγ，TNFβ和sVCAM-1）的水平没有显着差异。被测血液学参数均未出现差异。由于细胞因子表达的这些变化，可能导致暴露于SM的退伍军人的先天免疫功能异常，而这些反过来又可能导致无数疾病的发病率增加。在这些退伍军人，包括癌症中都有记载。未来的研究必须集中于研究循环细胞因子中这些变化的重要性及其对接触SM的退伍军人中各种疾病发展的潜在影响。

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