...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Abdominal visceral adiposity influences CD4(+) T cell cytokine production in pregnancy
【24h】

Abdominal visceral adiposity influences CD4(+) T cell cytokine production in pregnancy

机译：腹部内脏肥胖影响妊娠期CD4（+）T细胞细胞因子的产生

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Women with pre-gravid obesity are at risk for pregnancy complications. While the macrophage response of obese pregnant women categorized by body mass index (BMI) has been documented, the relationship between the peripheral CD4(+) T cell cytokine profile and body fat compartments during pregnancy is unknown. In this study, third trimester peripheral CD4(+) T cell cytokine profiles were measured in healthy pregnant women [n = 35; pre-pregnancy BMI: 18.5-40]. CD4(+) T cells were isolated from peripheral blood mononuclear cells and stimulated to examine their capacity to generate cytokines. Between 1 and 3 weeks postpartum, total body fat was determined by dual-energy X-ray absorptiometry and abdominal subcutaneous and visceral fat masses were determined by magnetic resonance imaging. Pearson's correlation was performed to assess relationships between cytokines and fat mass. Results showed that greater abdominal visceral fat mass was associated with a decrease in stimulated CD4(+) T cell cytokine expression. IFN-gamma, TNF-alpha, IL-12p70, IL-10 and IL-17A were inversely related to visceral fat mass. Chemokines CCL3 and IL-8 and growth factors G-CSF and FLT-3L were also inversely correlated. Additionally, total body fat mass was inversely correlated with FGF-2 while abdominal subcutaneous fat mass and BMI were unrelated to any CD4(+) T cell cytokine. In conclusion, lower responsiveness of CD4(+) T cell cytokines associated with abdominal visceral fat mass is a novel finding late in gestation. (C) 2014 Elsevier Ltd. All rights reserved.
机译：患有重性肥胖的女性有发生妊娠并发症的风险。虽然已记录了按体重指数（BMI）归类的肥胖孕妇的巨噬细胞反应，但怀孕期间外周CD4（+）T细胞细胞因子谱与体脂区隔之间的关系尚不清楚。在这项研究中，在健康孕妇中测量了妊娠中期的外周CD4（+）T细胞细胞因子概况[n = 35;孕前BMI：18.5-40]。从外周血单个核细胞中分离出CD4（+）T细胞，并对其进行刺激以检查其产生细胞因子的能力。产后1至3周内，通过双能X射线吸收法测定全身脂肪，并通过磁共振成像测定腹部皮下和内脏脂肪量。进行皮尔逊相关分析以评估细胞因子与脂肪量之间的关系。结果表明，较大的腹部内脏脂肪量与刺激的CD4（+）T细胞细胞因子表达的减少有关。 IFN-γ，TNF-α，IL-12p70，IL-10和IL-17A与内脏脂肪量成反比。趋化因子CCL3和IL-8与生长因子G-CSF和FLT-3L也呈负相关。此外，全身脂肪量与FGF-2成反比，而腹部皮下脂肪量和BMI与任何CD4（+）T细胞细胞因子无关。总之，与腹部内脏脂肪量相关的CD4（+）T细胞细胞因子的较低反应性是妊娠晚期的新发现。 （C）2014 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号