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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Cholesterol modulates the pressure response of DMPC membranes
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Cholesterol modulates the pressure response of DMPC membranes

机译：胆固醇调节DMPC膜的压力响应

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摘要

In this work, the effect of cholesterol on the pressure response of solid-supported phospholipid multilayers is analyzed. It is shown that DMPC multilayers become highly pressure-responsive by the incorporation of low amounts of cholesterol, resulting in a strong pressure-induced expansion of the bilayer spacing. This is accompanied by a high tendency of the multilayer system to detach from the substrate. Increasing the cholesterol concentration reduces the pressure-induced expansion and the membrane structure remains largely unchanged upon pressurization, consequently the stability of the multilayers improves. For a determination of the influence of the substrate, the pressure-dependent behavior of multilayers is compared to that of solid-supported bilayers and multi-lamellar vesicles in bulk solution. While single-supported bilayers remain largely unaffected by external pressure independent of their cholesterol content, multi-lamellar vesicles and multilayers behave similarly.
机译：在这项工作中，分析了胆固醇对固体支持的磷脂多层压力响应的影响。 结果表明，通过掺入低量的胆固醇，DMPC多层变得高度压力响应，从而产生强烈的双层间距的膨胀膨胀。 这伴随着多层系统的高趋势来从基板上脱离。 增加胆固醇浓度降低了压力诱导的膨胀，并且在加压时膜结构在很大程度上保持不变，因此多层改善的稳定性。 为了确定基板的影响，将多层的压力依赖性行为与本体溶液中固体支持的双层和多层层状囊泡进行比较。 虽然单支撑的双层仍然很大程度上不受外部压力不受其胆固醇含量的影响，但多层囊泡和多层的行为类似地。

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