...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines?
【24h】

DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines?

机译：DNA复制和间歇性交联的修复：二聚体纳米机的对称活化？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Eukaryotic DNA replication initiation and the Fanconi anemia pathway of interstrand crosslink repair both revolve around the recruitment of a set of DNA-processing factors onto a dimeric protein complex, which functions as a loading platform (MCM and FANCI-FANCD2 respectively). Here we compare and contrast the two systems, identifying a set of unresolved mechanistic questions. How is the dimeric loading platform assembled on the DNA? How can equivalent covalent modification of both factors in a dimer be achieved? Are multicomponent DNA-interacting machines built symmetrically around their dimeric loading platform? Recent biochemical reconstitution studies are starting to shed light on these issues. Graphical abstract Display Omitted Highlights ? DNA replication initiation requires the formation/modification of a symmetric dimer of MCM helicases bound to DNA. ? Similarly, interstrand crosslink repair requires mono-ubiquitination of the FANCI-FANCD2 heterodimer by a homo-dimeric enzyme. ? What role the symmetric FANCI-FANCD2 dimer plays in interstrand crosslink repair activation remains unclear.
机译：摘要真核DNA复制启动和Interstrand交联修复的FANCONI贫血途径围绕着一组DNA处理因子募集到二聚体蛋白质复合物上，其作为装载平台（MCM和FANCI-FANDD2）。在这里，我们比较和对比两个系统，识别一组未解决的机制问题。 DID中的二聚体加载平台如何在DNA上组装？如何实现两种因素的等效共价修改？多组分DNA交互机是否在其二聚体加载平台周围对称构建？最近的生化重建研究开始阐明这些问题。图形抽象显示省略了亮点？ DNA复制启动需要形成/修饰与DNA结合的MCM螺旋酶的对称二聚体。还类似地，Interstrand Crosslink修复需要通过同型二聚体酶进行单二二二二二二聚体的单次泛酸。还对称的Fanci-Fancd2二聚体在Interstrand Crosslink修复激活中扮演的角色尚不清楚。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号