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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Apomyoglobin is an efficient carrier for zinc phthalocyanine in photodynamic therapy oft tumors
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Apomyoglobin is an efficient carrier for zinc phthalocyanine in photodynamic therapy oft tumors

机译：Apomyoglobin是肿瘤光动力治疗中磷酞菁的锌酞菁的有效载体

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摘要

The spectral and the photophysical properties of phthalocyanines have made these dyes attractive for applications in photodynamic therapy of cancer. One important known issue of these compounds is their tendency to aggregate in aqueous media, which decreases their fluorescence, triplet, and singlet oxygen quantum yields. We report on the use of apomyoglobin as a carrier for zinc phthalocyanine (ZnPc) to overcome solubility limitations of the dye. We show that the protein is able to bind ZnPc in monomeric form, preserving its photophysics. Confocal fluorescence imaging of PC3 and HeLa cells, treated with the complex between ZnPc and apomyoglobin, demonstrates that the photosensitizer is uptaken quickly by cells. Illumination of treated cells strongly decreases viability, as demonstrated by live/dead fluorescence assay.
机译：酞菁的光谱和光学性质使这些染料对癌症的光动力治疗中的应用具有吸引力。 这些化合物的一个重要已知问题是它们在水性介质中聚集的倾向，其降低其荧光，三重态和单次氧量子产率。 我们报告使用亚磷蛋白作为锌酞菁（ZnPC）的载体，以克服染料的溶解性限制。 我们表明该蛋白质能够以单体形式结合ZnPC，保持其光学药物。 用ZnPC和亚硝基酚素之间的复合物处理的PC3和HeLa细胞的共焦荧光成像表明光敏剂通过细胞快速膨胀。 经处理细胞的照明强烈降低活力，如Live / Dead荧光测定所证明的那样。

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