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Biospecimen Complexity and the Evolution of Biobanks

机译：Biopecimen复杂性和Biobanks的演变

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摘要

Biospecimens are critical in driving health research. There is increased demand for scale and quality of biospecimens that in turn drives biobanking operational costs, influences utilization, and threatens the sustainability of individual biobanks. Biospecimen research has begun to inform the details of new biobanking standards and the steps of the biobanking process that are most important to focus on to achieve higher quality. This focus on quality is currently centered mostly on intrinsic features of biospecimens and their annotating data. This review highlights additional quality features that are important to researchers in determining the fit for purpose in their research. First, we define complex qualities as those that are mostly extrinsic to the individual biospecimen and data, and second, we provide data on the growth in demand for biospecimens with this type of quality in cancer research biobanks. Finally, we discuss why biospecimen complexity is a challenge for biobanks and utilization of existing collections, and provide examples of strategies biobanks can consider to improve their focus on this aspect of quality, as we predict that researcher demand for complex biospecimens will continue to expand in the future.
机译：Biopecimens在驾驶健康研究方面至关重要。对生物学中的规模和质量的需求增加，反过来推动生物管理运营成本，影响利用率，并威胁到个体生物汉的可持续性。 Biopecimen Research已开始通知新的Biobanking标准的详细信息，以及最重要的是重点达到更高质量的生物管理过程的步骤。这种对质量的关注目前主要用于生物开发谋的内在特征及其注释数据。此审查突出了额外的质量特征，对研究人员来说是在研究中确定适合的研究人员。首先，我们将复杂的品质定义为大多是对个人生物开发和数据外部的那些，而第二，我们在癌症研究Biobanks中提供了这种品质的生物学中需求增长的数据。最后，我们讨论了为什么Biobecen的复杂性是对生物人物和现有收集的利用的挑战，并提供战略Biobanks的例子可以考虑改善他们对质量的这种方面的关注，因为我们预测对复杂生物起草的研究人员需求将继续扩大未来。

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  • 来源
    《Biopreservation and biobanking》 |2019年第3期|共7页
  • 作者

    Hartman Victoria; Matzke Lise; Watson Peter H.;

  • 作者单位

    British Columbia Canc Victoria Ctr Deeley Res Ctr Biobanking &

    Biospecimen Res Serv 2410 Lee Ave Vancouver BC V8R 6V5 Canada;

    British Columbia Canc Victoria Ctr Deeley Res Ctr Biobanking &

    Biospecimen Res Serv 2410 Lee Ave Vancouver BC V8R 6V5 Canada;

    British Columbia Canc Victoria Ctr Deeley Res Ctr Biobanking &

    Biospecimen Res Serv 2410 Lee Ave Vancouver BC V8R 6V5 Canada;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    quality; complexity; utilization; sustainability;

    机译：质量;复杂性;利用;可持续性;

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