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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Tongluojiunao, a traditional Chinese medication with neuroprotective ability: A review of the cellular, molecular and physiological mediators of TLJN's effectiveness
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Tongluojiunao, a traditional Chinese medication with neuroprotective ability: A review of the cellular, molecular and physiological mediators of TLJN's effectiveness

机译：通络荣套，一种具有神经保护能力的中药药物：对TLJN有效性的细胞，分子和生理介质的综述

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摘要

The pressing need to discover more effective drugs for various CNS disorders has resurrected the idea of investigating the effectiveness of traditional medicines in modern science. Tongluojiunao (TLJN) is an example of revived modern herbal preparation based on traditional Chinese medicine (TCM) with a long history of administration for various types of cerebrovascular injuries and neurodegenerative diseases. TLJN is prepared from the herbal roots of Panax notoginseng (Sanchi) and dried fruits of Gardenia jasminoides (Cape Jasmine), and so far, it has demonstrated promising results in patients with vascular dementia and cerebral ischemic stroke. TLJN has also demonstrated therapeutic ability regarding the slowly-progressed neurodegenerative diseases like Alzheimer's disease. So it tempted us to undertake a thorough review of various features of TLJN therapeutic effects on the mentioned CNS conditions, including the cellular and molecular targets, inflammatory responses, neurogenesis and angiogenesis mediators and cognitive function. For this purpose, multiple global and local databases, including China National Knowledge Infrastructure (CNKI) were checked out and the retrieved information was grouped according to their scope of studies. Among these, TLJN is reported to restore the de-regulated cell-cell communication in the neurovascular unit, prevent the stress-related challenges imposed by ischemia/reperfusion insult, help with the cerebral tissue recovery after traumatic brain damage, avoid the epileptic seizure attack and limit the progression of Alzheimer's disease. We hope that the current review provides new insights into TLJN medication as a prospective neuroprotective medication for further more in-depth investigation in the future.
机译：迫切需要为各种CNS疾病发现更有效的药物复苏已经复活了研究现代科学中传统药物的有效性的想法。通罗省（TLJN）是基于中医（TCM）的现代草药制剂的历史悠久，历史悠久的各种类型的脑血管伤和神经变性疾病。 TLJN是由Panax Noginseng（Sanchi）的草本根源制备，栀子茉莉花（茉莉花）的干果，到目前为止，它已经证明了血管痴呆患者和脑缺血性卒中患者的有希望的结果。 TLJN还证明了关于慢慢进入的神经变性疾病等易患阿尔茨海默病的能力。因此，我们诱使我们对提及的CNS病症的各种特征进行彻底审查TLJN治疗效果的各种特征，包括细胞和分子靶标，炎症反应，神经发生和血管生成介质和认知功能。为此目的，检查了多个全球和本地数据库，包括中国国家知识基础设施（CNKI），并根据其研究范围进行检索到的信息。其中，据报道，TLJN恢复神经血管单元中的监管细胞 - 细胞通信，防止缺血/再灌注损伤施加的应力相关的挑战，帮助脑组织恢复在创伤性脑损伤后，避免癫痫发作攻击并限制阿尔茨海默病的进展。我们希望目前的审查能够为TLJN药物作为预期神经保护药物的新见解，以便将来进一步深入调查。

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