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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Extracellular calcium influx through L-type calcium channels, intracellular calcium currents and extracellular signal-regulated kinase signaling are involved in the abscisic acid-induced precognitive and anti-anxiety effects
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Extracellular calcium influx through L-type calcium channels, intracellular calcium currents and extracellular signal-regulated kinase signaling are involved in the abscisic acid-induced precognitive and anti-anxiety effects

机译：通过L型钙通道，细胞内钙电流和细胞外信号调节激酶信号传导的细胞外钙流入涉及脱钙酸诱导的预知和抗焦虑效应

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摘要

Abscisic acid (ABA), a critical phytohormone, is also produced in animal tissues. It has been reported that ABA has pro-cognitive and anti-anxiety effects in rats. However, its detailed mechanism has not yet been clarified. Here, the possible roles of extracellular and intracellular calcium store and ERK signaling were evaluated in pro-cognitive and anti-anxiety effects of ABA. Morris water maze (MWM) and plus maze tests were used to evaluate the learning and memory and anxiety-like behavior, respectively, in rats. The inhibitors of L-(nifedipine) and T-type (amiloride) calcium channels and endoplasmic reticulum Ca2+-ATPase (thapsigargin) were centrally (i.c.v.) injected 15 min before ABA. Hippocampal and prefrontal lobe levels of phosphorylated extracellular signal-regulated Kinase (p-ERK) were assessed by immunoblotting. The data showed that ABA has promoting effect on rat's performance in MWM task and induced anti-anxiety effect. In addition, nifedipine and thapsigargin significantly prevented while, amiloride had no effect on the mentioned effects of ABA. Furthermore, p-ERK levels were significantly increased in ABA-treated rats which were inhibited by nifedipine and thapsigargin pretreatment. It seems that the extracellular calcium influx through L-type calcium channels, intracellular calcium storage and ERK signaling are involved, at least in part, in the pro-cognitive and anti-anxiety effects of ABA.
机译：在动物组织中也产生了脱离酸（ABA），临界植物激素。据报道，ABA在大鼠中具有亲认知和抗焦虑作用。但是，它的详细机制尚未澄清。这里，在ABA的亲认知和抗焦虑效应中评估了细胞外和细胞内钙储存和ERK信号的可能作用。 Morris水迷宫（MWM）和Plus迷宫测试分别在大鼠中分别评估学习和记忆和焦虑的行为。 L-（NifeDiPine）和T型（Amiloride）钙通道和内质网Ca2 + -ATP酶（Thapsigargin）的抑制剂是中心（I.C.V.）在ABA之前注入15分钟。通过免疫印迹评估磷酸化细胞外信号调节激酶（P-ERK）的海马和前额叶水平。该数据显示，ABA促进了对大鼠MWM任务中的表现的影响，诱导抗焦虑作用。此外，硝苯地平和尾骨显着预防，而Amiloride对ABA的提及效果没有影响。此外，在ABA处理的大鼠中，P-ERK水平显着增加，所述大鼠被硝苯地平和尾剂预处理抑制。似乎通过L型钙通道，细胞内钙储存和ERK信号传导的细胞外钙流入，至少部分地参与了ABA的亲认知和抗焦虑效应。

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