Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes

Chang Xin; Shen Jirong; Yang Haiwei; Xu Yanan; Gao Wei; Wang Junling; Zhang Huiyun; He Shaoheng

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Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes

机译：CCR3在骨关节炎中的表达上调和CCR3介导的成纤维样滑膜细胞激活

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Objectives: Upregulated expression of CC chemokine receptor (CCR)3 was observed in osteoarthritis (OA) cartilage and chondrocytes, but expression of CCR3 on synovial tissue of OA remains unknown. Fibroblast-like synoviocyte (FLS) invasion in synovium appears one of the features of OA, but expression and function of CCR3 on FLS remain uninvestigated. We therefore explored them in the present study.

机译：目的：在骨关节炎（OA）软骨和软骨细胞中观察到CC趋化因子受体（CCR）3的表达上调，但在滑膜组织中CCR3的表达尚不清楚。滑膜中成纤维样滑膜细胞（FLS）的侵袭是OA的特征之一，但CCR3在FLS上的表达和功能尚待研究。因此，我们在本研究中探讨了它们。

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来源
《Cytokine》 |2016年第1期|共9页
作者
Chang Xin; Shen Jirong; Yang Haiwei; Xu Yanan; Gao Wei; Wang Junling; Zhang Huiyun; He Shaoheng;
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正文语种 eng
中图分类细胞生物学;
关键词
Osteoarthritis; CCR3; Fibroblast-like synoviocyte; Eotaxin-1; MMP-9;

机译：骨关节炎;CCR3;成纤维样滑膜细胞;趋化因子-1;MMP-9;

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专利

1. Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes [J] . Chang Xin, Shen Jirong, Yang Haiwei, Cytokine . 2016,第1期

机译：CCR3在骨关节炎中的表达上调和CCR3介导的成纤维样滑膜细胞激活
2. Denbinobin upregulates miR-146a expression and attenuates IL-1 |3-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes [J] . Chia-Ron Yang, Kao-Shang Shih, Jing-Ping Liou Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte." . 2014,第11期

机译：Denbinobin上调MiR-146a表达，并衰减IL-1 | 3诱导的骨关节炎成纤维细胞样Synoviocytes的ICAM-1和VCAM-1表达的上调
3. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. [J] . Wang CT, Lin YT, Chiang BL, Osteoarthritis and cartilage . 2006,第12期

机译：高分子量透明质酸下调了早期骨关节炎患者成纤维样滑膜细胞中骨关节炎相关细胞因子和酶的基因表达。
4. Effect of different molecular weight Hyaluronans on osteoarthritis-related factors in fibroblast-like synoviocytes from patients with tibia plateau fracture [C] . Horng-Chaung Hsu, Teng-Le Huang, Feng-Huei Lin, IEEE Annual Northeast Bioengineering Conference . 2009

机译：不同分子量透明质酸对胫骨平台骨折患者成纤维样滑膜细胞骨关节炎相关因子的影响
5. The genomic targets of p38 mitogen activated protein kinase mediating tumor necrosis factor alpha signaling in fibroblast-like synoviocytes [D] . Zer, Cindy 2008

机译：p38丝裂原活化蛋白激酶介导肿瘤坏死因子α信号在成纤维样滑膜细胞中的基因组靶点。
6. IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation [O] . Seon-Yeong Lee, Seung-Ki Kwok, Hye-Jin Son, 2013

机译：IL-17介导的Bcl-2表达通过STAT3激活来调节类风湿关节炎中成纤维样滑膜细胞的存活
7. IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation [O] . Seon-Yeong Lee, Seung-Ki Kwok, Hye-Jin Son, 2013

机译：IL-17介导的Bcl-2表达通过STAT3激活来调节类风湿关节炎中成纤维样滑膜细胞的存活

Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes

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