Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma

Wang Ya-Dong; Sun Xue-Jun; Yin Jia-Jun; Yin Min; Wang Wei; Nie Zhe-Qun; Xu Jian

首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma

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Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma

机译：长期非编码RNA FEZF1-AS1通过jak2 / stat3信号通路在人肝细胞癌中促进细胞侵袭和上皮 - 间充质转换

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Long non-coding RNAs (lncRNAs) have emerged as key regulators in the development of hepatocellular carcinoma (HCC). In the present study, we explored the expression profile and biological role of lncRNA FEZF1-AS1 in HCC. We observed remarkable upregulation of FEZF1-AS1 in HCC tissues and cell lines, and high FEZF1-AS1 expression was correlated with aggressive phenotypes and poor prognosis of HCC patients. Furthermore, we found that FEZF1-AS1 knockdown markedly inhibited the proliferation of HCC cells by inducing cell cycle arrest. In addition, FEZF1-AS1 knockdown suppressed HCC tumor growth in vivo. Moreover, FEZF1-AS1 knockdown inhibited the migration and invasion of HCC cells through suppression of JAK2/STAT3 signaling-mediated epithelial-mesenchymal transition (EMT). In conclusion, the present study for the first time demonstrated that FEZF1-AS1 serves as an oncogenic lncRNA in human HCC and implicated FEZF1-AS1 as a valuable therapeutic target for HCC treatment.

机译：长期非编码RNA（LNCRNA）被出现为肝细胞癌（HCC）的关键调节剂。在本研究中，我们探讨了HCC中LNCRNA FEZF1-AS1的表达型谱和生物学作用。我们观察到HCC组织和细胞系中FEZF1-AS1的显着上调，高FEZF1-AS1表达与腐蚀性表型和HCC患者的预后不良。此外，我们发现FEZF1-AS1敲低明显抑制细胞周期骤停抑制HCC细胞的增殖。此外，FEZF1-AS1敲低抑制了体内HCC肿瘤生长。此外，FEZF1-AS1敲低通过抑制JAK2 / Stat3信号介导的上皮 - 间充质转换（EMT）抑制HCC细胞的迁移和侵袭。总之，本研究首次证明FEZF1-AS1用作人HCC中的致癌LNCRNA，并将FEZF1-AS1归因于HCC治疗的有价值的治疗靶标。

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《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie》 |2018年第2018期|共8页
作者
Wang Ya-Dong; Sun Xue-Jun; Yin Jia-Jun; Yin Min; Wang Wei; Nie Zhe-Qun; Xu Jian;
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作者单位

Xi An Jiao Tong Univ Dept Gen Surg Affiliated Hosp 1 277 West Yanta Rd Xian 710061 Shaanxi;

Xi An Jiao Tong Univ Dept Gen Surg Affiliated Hosp 1 277 West Yanta Rd Xian 710061 Shaanxi;

Dalian Univ Affiliated Zhongshan Hosp Dept Gen Surg Dalian 116001 Peoples R China;

Dalian Univ Affiliated Zhongshan Hosp Dept Gen Surg Dalian 116001 Peoples R China;

Dalian Univ Affiliated Zhongshan Hosp Dept Gen Surg Dalian 116001 Peoples R China;

Dalian Univ Affiliated Zhongshan Hosp Dept Gen Surg Dalian 116001 Peoples R China;

Dalian Univ Affiliated Zhongshan Hosp Dept Gen Surg Dalian 116001 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
FEZF1-AS1; Hepatocellular carcinoma; Cell cycle; Epithelial-mesenchymal transition; JAK2/STAT3 signaling pathway;

机译：FezF1-AS1;肝细胞癌;细胞周期;上皮 - 间充质转换;JAK2 / Stat3信号通路;

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1. Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma [J] . Wang Ya-Dong, Sun Xue-Jun, Yin Jia-Jun, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2018,第期

机译：长期非编码RNA FEZF1-AS1通过jak2 / stat3信号通路在人肝细胞癌中促进细胞侵袭和上皮 - 间充质转换
2. B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway [J] . Fu-biao Kang, Ling Wang, Heng-chuan Jia, Cancer Cell International . 2015,第1期

机译：B7-H3通过JAK2 / STAT3 / Slug信号通路靶向上皮到间质转化，从而促进肝细胞癌的侵袭和侵袭
3. B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway [J] . Fu-biao Kang, Ling Wang, Heng-chuan Jia, Cancer Cell International . 2015,第1期

机译：B7-H3通过JAK2 / STAT3 / Slug信号通路靶向上皮到间质转化，从而促进肝细胞癌的侵袭和侵袭
4. PLK1 Promotes Invasion of Esophageal Squamous Cell Carcinoma Cells through Inducing Epithelial-mesenchymal Transition [C] . Jiyu Ju, Wenjing Yu, Chunling Zhao International Conference on Applied Sciences, Engineering and Technology . 2014

机译：PLK1通过诱导上皮 - 间充质转换来促进食管鳞状细胞癌细胞的侵袭
5. The anti-cancer activities of Paeoniae Radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms. [D] . Li, Lok Yee Mandy. 2004

机译：e药提取物对人肝癌细胞HepG2和多药耐药人肝癌细胞R-HepG2的抗癌活性及其作用机制。
6. B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway [O] . Fu-biao Kang, Ling Wang, Heng-chuan Jia, 2015

机译：B7-H3通过JAK2 / STAT3 / Slug信号通路靶向上皮到间质转化从而促进肝细胞癌的侵袭和侵袭
7. B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway [O] . 2015

机译：B7-H3通过JAK2 / STAT3 / Slug信号通路靶向上皮到间质转化，从而促进肝细胞癌的侵袭和侵袭

Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma

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